Tumor-derived extracellular vesicles in melanoma immune response and immunotherapy

被引：11

作者：

Zhou, Qiujun ^{[1
]}

Yan, Yan ^{[2
]}

Li, Yuanyan ^{[3
]}

Fu, Hongyang ^{[3
]}

Lu, Dingqi ^{[1
]}

Li, Zhaoyi ^{[1
]}

Wang, Yihan ^{[1
]}

Wang, Jinhui ^{[4
]}

Zhu, Haijia ^{[5
]}

Ren, Jianlei ^{[6
]}

Luo, Hongbin ^{[6
]}

Tao, Maocan ^{[6
]}

Cao, Yi ^{[6
]}

Wei, Shenyu ^{[7
]}

Fan, Shasha ^{[8
]}

机构：

[1] Zhejiang Chinese Med Univ, Dept Clin Med Coll 1, Hangzhou 310000, Peoples R China

[2] Beijing Univ Chinese Med, Affiliated Hosp 3, 51 Anwai Xiaoguanjie, Beijing 100029, Peoples R China

[3] Zhejiang Chinese Med Univ, Zhejiang Prov Hosp Tradit Chinese Med, Affiliated Hosp 1, Hangzhou 310000, Peoples R China

[4] Wenzhou City Hosp tradit Chinese Med & Western Med, Wenzhou 310000, Peoples R China

[5] Hangzhou Childrens Hosp, Hangzhou 310000, Peoples R China

[6] Zhejiang Chinese Med Univ, Affiliated Hosp 1, Hangzhou 310000, Peoples R China

[7] Zhejiang Univ, Affiliated Hosp 2, Dept Hepatopancreato Biliary Surg, Sch Med, Hangzhou 310000, Zhejiang, Peoples R China

[8] Hangzhou Med Coll, Zhejiang Prov Peoples Hosp, Affiliated Peoples Hosp, Ctr Plast & Reconstruct Surg, Hangzhou 310014, Zhejiang, Peoples R China

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2022年 / 156卷

关键词：

Tumor; Extracellular vesicles; Melanoma; Immune response; Immunotherapy; ANTIGEN PRESENTATION; SUPPRESSOR-CELLS; EXOSOMES; MACROPHAGE; SECRETION; ESCAPE; GROWTH;

D O I：

10.1016/j.biopha.2022.113790

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Tumor-derived extracellular vesicles (EVs) are key immune regulators of the tumor microenvironment. They reshape the immune microenvironment and prevent antitumor immune responses via their immunosuppressive cargo, thereby determining cancer responsiveness to treatment. In the immune microenvironment of melanoma, tumor-derived EVs influence tumor progression by regulating innate and adaptive immune responses. Tumor-derived EV-based therapy is a cutting-edge and promising strategy for inhibiting melanoma progression and enhancing antitumor immunity. This review aimed to summarize the regulatory roles of EVs in the immune responses and immunotherapy of patients with melanoma. This paper provided insights into future exploration directions and potential clinical strategies targeting EVs for melanoma treatment.

引用

页数：9

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