Identification of a long variant of mRNA encoding the NR3 subunit of the NMDA receptor: its regional distribution and developmental expression in the rat brain

被引：79
作者：
Sun, LX
Margolis, FL
Shipley, MT
Lidow, MS
机构：
[1] Univ Maryland, Dept Oral & Craniofacial Biol Sci, Baltimore, MD 21201 USA
[2] Univ Maryland, Dept Anat & Neurobiol, Baltimore, MD 21201 USA
[3] Univ Maryland, Program Neurosci, Baltimore, MD 21201 USA
来源：
FEBS LETTERS | 1998年 / 441卷 / 03期
基金：
美国国家卫生研究院;
关键词：
NMDA receptor; NR3; subunit; variant; cloning; phosphorylation; distribution; development;
D O I：
10.1016/S0014-5793(98)01590-7
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A longer variant of rat mRNA encoding the NR3 subunit of the NMDA receptor has been identified. It contains a 60-bp insertion at the nucleotide position 3007 in the intracellular domain of the C-terminal of the previously cloned variant. Therefore, the NR3 mRNA exists in at least two variants - with the insert (NR3-long; NR3-1) and without the insert (NR3-short; NR3-s), The NR3-1 variant is expressed throughout the adult rat brain. Moreover, this variant predominates in the occipital and entorhinal cortices, thalamus and cerebellum. Analysis of NR3-1 development indicates that it is regulated in a region-specific manner. (C) 1998 Federation of European Biochemical Societies.
引用
收藏
页码：392 / 396
页数：5
相关论文
共 27 条
[1]   QUISQUALATE METABOTROPIC RECEPTORS MODULATE NMDA CURRENTS AND FACILITATE INDUCTION OF LONG-TERM POTENTIATION THROUGH PROTEIN-KINASE-C [J].
ANIKSZTEJN, L ;
OTANI, S ;
BENARI, Y .
EUROPEAN JOURNAL OF NEUROSCIENCE, 1992, 4 (06) :500-505
[2]   SUSTAINED POTENTIATION OF NMDA RECEPTOR MEDIATED GLUTAMATE RESPONSES THROUGH ACTIVATION OF PROTEIN-KINASE-C BY A MU-OPIOID [J].
CHEN, L ;
HUANG, LYM .
NEURON, 1991, 7 (02) :319-326
[3]  
CIABARRA AM, 1995, J NEUROSCI, V15, P6498
[4]   Increased NMDA current and spine density in mice lacking the NMDA receptor subunit NR3A [J].
Das, S ;
Sasaki, YF ;
Rothe, T ;
Premkumar, LS ;
Takasu, M ;
Crandall, JE ;
Dikkes, P ;
Conner, DA ;
Rayudu, PV ;
Cheung, W ;
Chen, HSV ;
Lipton, SA ;
Nakanishi, N .
NATURE, 1998, 393 (6683) :377-381
[5]   CLONING OF AN APPARENT SPLICE VARIANT OF THE RAT N-METHYL-D-ASPARTATE RECEPTOR NMDAR1 WITH ALTERED SENSITIVITY TO POLYAMINES AND ACTIVATORS OF PROTEIN-KINASE-C [J].
DURAND, GM ;
GREGOR, P ;
ZHENG, X ;
BENNETT, MVL ;
UHL, GR ;
ZUKIN, RS .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (19) :9359-9363
[6]   SPLICE VARIANTS OF THE N-METHYL-D-ASPARTATE RECEPTOR NR1 IDENTIFY DOMAINS INVOLVED IN REGULATION BY POLYAMINES AND PROTEIN-KINASE-C [J].
DURAND, GM ;
BENNETT, MVL ;
ZUKIN, RS .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (14) :6731-6735
[7]   REGULATED SUBCELLULAR-DISTRIBUTION OF THE NR1 SUBUNIT OF THE NMDA RECEPTOR [J].
EHLERS, MD ;
TINGLEY, WG ;
HUGANIR, RL .
SCIENCE, 1995, 269 (5231) :1734-1737
[8]  
Farbman Albert I., 1994, Seminars in Cell Biology, V5, P3
[9]   ZINC POTENTIATES AGONIST-INDUCED CURRENTS AT CERTAIN SPLICE VARIANTS OF THE NMDA RECEPTOR [J].
HOLLMANN, M ;
BOULTER, J ;
MARON, C ;
BEASLEY, L ;
SULLIVAN, J ;
PECHT, G ;
HEINEMANN, S .
NEURON, 1993, 10 (05) :943-954
[10]  
ISHII T, 1993, J BIOL CHEM, V268, P2836
123