Physical capability predicts mortality in late mid-life as well as in old age: Findings from a large British cohort study

被引:23
作者
Keevil, Victoria L. [1 ,2 ]
Luben, Robert [1 ]
Hayat, Shabina [1 ]
Sayer, Avan A. [3 ,4 ,5 ,6 ]
Wareham, Nicholas J. [7 ]
Khaw, Kay-Tee [1 ]
机构
[1] Univ Cambridge, Dept Publ Hlth & Primary Care, Strangeways Res Lab, Cambridge CB1 8RN, England
[2] Cambridge Univ Hosp NHS Fdn Trust, Addenbrookes Hosp, Med Older People, Cambridge CB2 0QQ, England
[3] Newcastle Univ, NIHR Newcastle Biomed Res Ctr, Newcastle Upon Tyne, Tyne & Wear, England
[4] Newcastle Tyne Hosp NHS Fdn Trust, Newcastle Upon Tyne, Tyne & Wear, England
[5] Newcastle Univ, Inst Neurosci, AGE Res Grp, Newcastle Upon Tyne, Tyne & Wear, England
[6] Newcastle Univ, Inst Ageing, Newcastle Upon Tyne, Tyne & Wear, England
[7] Univ Cambridge, MRC, Epidemiol Unit, Inst Metab Sci, Addenbrookes Biomed Campus, Cambridge CB2 0QQ, England
基金
英国惠康基金; 英国医学研究理事会;
关键词
Physical performance; Mortality; Epidemiology; Mid-late life; ALL-CAUSE; STRENGTH; QUESTIONNAIRE; PERFORMANCE; CANCER; SPEED; RISK;
D O I
10.1016/j.archger.2017.10.001
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Introduction: Low physical capability predicts mortality, perhaps by association with co-morbidity. However, few studies include participants <70 years old with lower co-morbidity burdens compared to older adults. We examined relationships between usual walking speed (UWS), timed chair stands speed, grip strength, standing balance and all-cause mortality in 8477 participants aged 48-92 years enrolled in the European Prospective Investigation of Cancer-Norfolk study. Methods: Participants (55.1% female) were followed up for 6.0 years (inter-quartile range 4.6, 7.5). Associations were examined using Cox proportional hazards regression by age-group (<70 years versus >= 70 years) and then in the whole cohort adjusted for age, sex, anthropometry, history of diabetes/stroke/myocardial infarction/cancer, smoking, alcohol intake, socioeconomic status, television viewing time and physical activity. Results: Age and sex adjusted associations were similar in younger and older participants (P-interaction all > 0.05) and those with lower physical capability had higher mortality risk. For example, in those < 70 years old hazard ratios (95% confidence interval) for mortality in the third, second and lowest sex-specific quartiles of UWS compared to the highest were 1.21 (0.75, 1.96), 2.11 (1.35, 3.28) and 2.91 (1.84, 4.62) and in participants >= 70 years old were 1.19 (0.73, 1.95), 2.09 (1.35, 3.24) and 2.64 (1.73, 4.02) respectively. In the whole cohort, strong associations between all physical capability tests and mortality persisted after multivariable adjustment and after excluding participants with co-morbidity. Conclusions: Physical capability was independently predictive of future mortality risk with similar associations in late mid-life, when co-morbidity burden is lower, as at older age.
引用
收藏
页码:77 / 82
页数:6
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