The effects of the dietary polyphenol resveratrol on human healthy aging and lifespan

被引：47

作者：

Fernandez, Agustin F. ^{[1
]}

Fraga, Mario F. ^{[1
,2
]}

机构：

[1] Univ Oviedo, HUCA, IUOPA, Canc Epigenet Lab, Oviedo, Spain

[2] CNB CSIC, Natl Biotechnol Ctr, Dept Immunol & Oncol, Madrid, Spain

来源：

EPIGENETICS | 2011年 / 6卷 / 07期

关键词：

resveratrol; lifespan; aging; SIRT1; cancer; ACTIVATED PROTEIN-KINASE; CANCER CHEMOPREVENTIVE AGENT; STEM-CELLS; CALORIE RESTRICTION; CLINICAL-IMPLICATIONS; TELOMERASE ACTIVITY; ALZHEIMERS-DISEASE; SIRTUIN SYSTEM; DEFICIENT MICE; POTENTIAL ROLE;

D O I：

10.4161/epi.6.7.16499

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The physiological effects of the dietary polyphenol resveratrol are being extensively studied. Resveratrol has been proposed to promote healthy aging and to increase lifespan, primarily through the activation of the class III histone deacetylases (sirtuins). Although its positive effects are evident in yeast and mice, they still have to be confirmed in humans. The molecular mechanisms involved in the processes are not fully understood because resveratrol may have other targets than sirtuins and the direct activation of sirtuins by resveratrol is under debate.

引用

页码：870 / 874

页数：5

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