Dietary and biomarker estimates of fatty acids and risk of colorectal cancer

被引:67
作者
Hodge, Allison M. [1 ]
Williamson, Elizabeth J. [2 ,3 ]
Bassett, Julie K. [1 ]
MacInnis, Robert J. [1 ,4 ]
Giles, Graham G. [1 ,4 ]
English, Dallas R. [1 ,4 ]
机构
[1] Canc Council Victoria, Canc Epidemiol Ctr, Melbourne, Vic 3004, Australia
[2] Farr Inst Hlth Informat Res, London NW1 2DA, England
[3] London Sch Hyg & Trop Med, Dept Med Stat, London WC1E 7H1, England
[4] Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Melbourne, Vic 3010, Australia
基金
英国医学研究理事会;
关键词
fatty acids; diet; phospholipids; colorectal cancer; prospective study; CAROLINA COLON-CANCER; PROSPECTIVE COHORT; AFRICAN-AMERICANS; RECTAL-CANCER; MARINE N-3; FISH; PLASMA; WOMEN; CONSUMPTION; MEN;
D O I
10.1002/ijc.29479
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The associations between intake of or circulating fatty acids and risk of colorectal cancer (CRC) are unclear. We examined prospectively the associations between dietary or biomarker fatty acids and CRC. For 41,514 men and women, aged 40-69 years, baseline (1990-94) dietary intakes of fatty acids were estimated using a food frequency questionnaire and plasma phospholipid (PPL) fatty acids were measured for 4,205 participants including 395 CRC cases, according to a case-cohort design. Hazard ratios were computed using Cox regression adjusting for education, alcohol intake, smoking status, physical activity and total energy intake; and stratified for gender, ethnicity and family history of cancer, with age as the time scale. We assessed the heterogeneity of associations with colon and rectal cancers. PPL saturated fatty acids (SFAs) were positively associated with CRC risk, while total n-3 polyunsaturated fatty acids (PUFA) and long chain marine n-3 PUFAs showed inverse associations, significant only for 22:5 n-3. No significant associations were observed for dietary fatty acid intakes but positive associations with CRC of borderline significance were seen for both dietary and PPL linoleic acid. Positive associations with dietary palmitic acid (16:0), MUFAs and n-6 PUFAs were seen for rectal but not colon cancers. PPL 22:6 n-3 was inversely associated with rectal cancer. Limiting intakes of SFAs and MUFAs could be assisted by following existing guidelines to limit red and processed meats which are important sources in the Australian diet. Our observations regarding linoleic acid should be examined further. What's new? While there is considerable evidence that diet is associated with colorectal cancer (CRC) risk, the associations for specific fatty acids remain unclear. Here, the authors prospectively examine associations between dietary intake estimates or plasma phospholipids (PPL) estimates of fatty acids and incident CRC. PPL saturated fat (SF) is positively associated with incident CRC and dietary SF with rectal cancer, while long chain n-3 fats are inversely associated with both. Following guidelines to limit red and processed meat would help reduce saturated fatty acids intake; the adverse association with linoleic acid, found in margarines and vegetable oils, requires further confirmation.
引用
收藏
页码:1224 / 1234
页数:11
相关论文
共 43 条
  • [1] [Anonymous], 2007, Food, Nutrition, Physical Activity, and the Prevention of Cancer: a Global Perspective
  • [2] [Anonymous], 1998, NAT NUTR SURV NUTR I
  • [3] [Anonymous], 2000, AUST J NUTR DIET
  • [4] Biomarkers of fat and fatty acid intake
    Arab, L
    [J]. JOURNAL OF NUTRITION, 2003, 133 (03) : 925S - 932S
  • [5] Abnormalities in plasma and red blood cell fatty acid profiles of patients with colorectal cancer
    Baró, L
    Hermoso, JC
    Núñez, MC
    Jiménez-Rios, JA
    Gil, A
    [J]. BRITISH JOURNAL OF CANCER, 1998, 77 (11) : 1978 - 1983
  • [6] Tissue levels of fish fatty acids and risk of colorectal adenomas: a case-control study (Netherlands)
    Busstra, MC
    Siezen, CLE
    Grubben, MJAL
    van Kranen, HJ
    Nagengast, FM
    van't Veer, P
    [J]. CANCER CAUSES & CONTROL, 2003, 14 (03) : 269 - 276
  • [7] Marine n-3 and saturated fatty acids in relation to risk of colorectal cancer in Singapore Chinese: A prospective study
    Butler, Lesley M.
    Wang, Renwei
    Koh, Woon-Puay
    Stern, Mariana C.
    Yuan, Jian-Min
    Yu, Mimi C.
    [J]. INTERNATIONAL JOURNAL OF CANCER, 2009, 124 (03) : 678 - 686
  • [8] Plasma phospholipid fatty acid concentrations and risk of gastric adenocarcinomas in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST)
    Chajes, Veronique
    Jenab, Mazda
    Romieu, Isabelle
    Ferrari, Pietro
    Dahm, Christina C.
    Overvad, Kim
    Egeberg, Rikke
    Tjonneland, Anne
    Clavel-Chapelon, Francoise
    Boutron-Ruault, Marie-Christine
    Engel, Pierre
    Teucher, Birgit
    Kaaks, Rudolf
    Floegel, Anna
    Boeing, Heiner
    Trichopoulou, Antonia
    Dilis, Vardis
    Karapetyan, Tina
    Mattiello, Amalia
    Tumino, Rosario
    Grioni, Sara
    Palli, Domenico
    Vineis, Paolo
    Bueno-de-Mesquita, H. Bas
    Numans, Mattijs E.
    Peeters, Petra H. M.
    Lund, Eiliv
    Navarro, Carmen
    Ramon Quiros, Jose
    Sanchez-Cantalejo, Emilio
    Barricarte Gurrea, Aurelio
    Dorronsoro, Miren
    Regner, Sara
    Sonestedt, Emily
    Wirfaelt, Elisabet
    Khaw, Kay-Tee
    Wareham, Nick
    Allen, Naomi E.
    Crowe, Francesca L.
    Rinaldi, Sabina
    Slimani, Nadia
    Carneiro, Fatima
    Riboli, Elio
    Gonzalez, Carlos A.
    [J]. AMERICAN JOURNAL OF CLINICAL NUTRITION, 2011, 94 (05) : 1304 - 1313
  • [9] Dietary Intake of ω-6 and ω-3 Fatty Acids and Risk of Colorectal Cancer in a Prospective Cohort of US Men and Women
    Daniel, Carrie R.
    McCullough, Marjorie L.
    Patel, Roshni C.
    Jacobs, Eric J.
    Flanders, William D.
    Thun, Michael J.
    Calle, Eugenia E.
    [J]. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2009, 18 (02) : 516 - 525
  • [10] English DR, 2004, CANCER EPIDEM BIOMAR, V13, P1509