Breast cancer metastasis to the bone: mechanisms of bone loss

被引:221
作者
Chen, Yu-Chi [1 ]
Sosnoski, Donna M. [1 ]
Mastro, Andrea M. [1 ]
机构
[1] Penn State Univ, Dept Biochem & Mol Cell Biol, University Pk, PA 16802 USA
关键词
OSTEOLYTIC LESIONS; TUMOR; RESORPTION; GROWTH; EXPRESSION; MODEL; OSTEOCLASTS; ADHESION; CELLS; OSTEOPONTIN;
D O I
10.1186/bcr2781
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Breast cancer frequently metastasizes to the skeleton, interrupting the normal bone remodeling process and causing bone degradation. Osteolytic lesions are the end result of osteoclast activity; however, osteoclast differentiation and activation are mediated by osteoblast production of RANKL (receptor activator for NF kappa B ligand) and several osteoclastogenic cytokines. Osteoblasts themselves are negatively affected by cancer cells as evidenced by an increase in apoptosis and a decrease in proteins required for new bone formation. Thus, bone loss is due to both increased activation of osteoclasts and suppression of osteoblasts. This review summarizes the current understanding of the osteolytic mechanisms of bone metastases, including a discussion of current therapies.
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页数:11
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