Human herpesvirus 6 latently infects early bone marrow progenitors in vivo

被引：96

作者：

Luppi, M

Barozzi, P

Morris, C

Maiorana, A

Garber, R

Bonacorsi, G

Donelli, A

Marasca, R

Tabilio, A

Torelli, G ^{[1
]}

机构：

[1] Univ Modena, Dept Med Sci, Sect Hematol, I-41100 Modena, Italy

[2] Univ Modena, Dept Pathol, I-41100 Modena, Italy

[3] Univ Perugia, Dept Clin & Expt Med, Clin Hematol & Immunol, I-06100 Perugia, Italy

[4] Christchurch Sch Med, Dept Pathol, Cytogenet & Mol Oncol Unit, Christchurch, New Zealand

[5] PathoGenesis Corp, Seattle, WA USA

来源：

JOURNAL OF VIROLOGY | 1999年 / 73卷 / 01期

关键词：

D O I：

10.1128/JVI.73.1.754-759.1999

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We have studied the in vivo tropism of human herpesvirus 6 (HHV-6) for hemopoietic cells in patients with latent HHV-6 infection. Having used a variety of cell purification, molecular, cytogenetic, and immunocytochemical procedures, we report the first evidence that HHV-6 latently infects early bone marrow progenitor cells and that HHV-6 may be transmitted longitudinally to cells which differentiate along the committed pathways.

引用

收藏

页码：754 / 759

页数：6

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