Regulation of iodothyronine deiodinases and sodium iodide symporter mRNA expression by perchlorate in larvae and adult Chinese rare minnow (Gobiocypris rarus)

被引：20
作者：
Li, Wei [1 ]
Zha, Jinmiao [1 ]
Yang, Lihua [1 ]
Li, Zhaoli [1 ]
Wang, Zijian [1 ]
机构：
[1] Chinese Acad Sci, Ecoenvironm Sci Res Ctr, State Key Lab Environm Aquat Chem, Beijing 100085, Peoples R China
来源：
MARINE POLLUTION BULLETIN | 2011年 / 63卷 / 5-12期
基金：
中国国家自然科学基金;
关键词：
Perchlorate; Deiodinase enzymes; Sodium iodide symporter (nis); Rare minnow (Gobiocypris rarus); THYROID-FUNCTION; AMMONIUM-PERCHLORATE; GENE-EXPRESSION; FATHEAD MINNOW; SURFACE-WATER; BOTTLED WATER; EXPOSURE; CONTAMINANTS; PITUITARY; GROWTH;
D O I：
10.1016/j.marpolbul.2011.02.006
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
Perchlorate is a widespread contaminant in the aquatic environment. In the present work, the expressions of deiodinase enzymes (d1, d2, and d3) and sodium iodide symporter (nis) genes were determined after larval and adult rare minnow (Gobiocypris rarus) exposed to 5 and 50 mu g/L perchlorate for 21 days. The results showed that deflation of swim bladder development was observed in larvae at 50 mu g/L perchlorate treatment. An up-regulation of the d2 and nis mRNA levels were observed in the larve and in brain of adults. Meanwhile the expressions of d3 mRNA levels were significantly down-regulated in the liver. These results indicate the changes in d2, nis, and d3 mRNA expression brings about increased outer-ring deiodination, idodine uptake, and a further decrease of inner-ring deiodination, respectively reflecting auto-regulation of hypothalamic-pituitary-thyroid (HPT) axis in adult after perchlorate exposure. The larval fish development could be affected by perchlorate at environmentally relevant concentrations. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：350 / 355
页数：6
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