Genistein, an epigenome modifier during cancer prevention

被引：50

作者：

Zhang, Yukun ^{[1
]}

Chen, Hong ^{[1
]}

机构：

[1] Univ Illinois, Dept Food Sci & Human Nutr, Urbana, IL 61801 USA

来源：

EPIGENETICS | 2011年 / 6卷 / 07期

关键词：

soy isoflavone; cancer epigenetics; DNA methylation; histone code; early life exposure; maternal genistein; SOY ISOFLAVONE GENISTEIN; TUMOR-SUPPRESSOR GENES; CELL-CYCLE ARREST; PROSTATE-CANCER; DNA METHYLATION; HISTONE MODIFICATION; GROWTH-INHIBITION; HYPERMETHYLATION; DIETARY; DEMETHYLATION;

D O I：

10.4161/epi.6.7.16315

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Dietary compounds have been observed to have a great potential to regulate the epigenome, which is disrupted and reprogrammed during carcinogenesis. Because of their close association with cancer development, DNA methylation patterns have been used as a crucial marker for the study of cancer-related epigenetics. There is immense evidence indicating that dietary components play a critical role in cancer development. Genistein, one of the soy-derived bioactive isoflavones, affects tumorigenesis through epigenetic regulations. By modulating chromatin configuration and DNA methylation, genistein activates tumor suppressor genes and affects cancer cell survival. Here, we summarize and discuss both in vitro and in vivo studies in the field that investigate the effect of genistein on histone modifications and DNA methylation. The promising role of genistein in cancer prevention and therapeutic applications will be discussed from an epigenetic point of view.

引用

页码：888 / 891

页数：4

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