Synthesis and Biological Activities of Oxadiazole Derivatives: A Review

被引：68

作者：

Vaidya, Ankur ^{[1
]}

Jain, Shweta ^{[2
]}

Jain, Priyanka ^{[3
]}

Jain, Prachi ^{[3
]}

Tiwari, Nidhi ^{[3
]}

Jain, Roshni ^{[3
]}

Jain, Rashi ^{[3
]}

Jain, Abhishek K. ^{[2
]}

Agrawal, Ram K. ^{[2
]}

机构：

[1] UPRIMS & R Saifai, Pharm Coll, Etawah, Uttar Pradesh, India

[2] Dr Hari Singh Gour Vishwavidyalaya, Dept Pharmaceut Sci, Sagar 470003, Madhya Pradesh, India

[3] Bhagyoday Tirth Pharm Coll, Sagar 470003, Madhya Pradesh, India

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2016年 / 16卷 / 10期

关键词：

Anti-bacterial; anticonvulsant; antifungal; anti-inflammatory; analgesic; anticancer; oxadiazole; N-OXIDE DERIVATIVES; POTENTIAL ANTITRYPANOSOMAL DRUGS; ANTIMYCOBACTERIAL ACTIVITY; PHARMACOLOGICAL PROPERTIES; ANTIINFLAMMATORY ACTIVITY; ANTICONVULSANT ACTIVITY; ANTIVIRAL EVALUATION; 1,2,4-OXADIAZOLES; ANTIBACTERIAL; ANALOGS;

D O I：

10.2174/1389557516666160211120835

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Recently, there has been wide interest in compounds containing the oxadiazole scaffold because of their unique chemical structure and their broad spectrum of biological properties. This review provides readers with an overview of the main synthetic methodologies for oxadiazoles and of their broad spectrum of pharmacological activities such as, anti-microbial, anti-fungal activity, antiviral, anti-tubercular, anti-inflammatory, anti-convulsant, anti-angiogenic, anti-proliferative, analgesic, anti-oedema and in alzheimer activity, which were reported over the past years.

引用

页码：825 / 845

页数：21

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