Isosteviol-amino Acid Conjugates as Highly Efficient Organocatalysts for the Asymmetric One-pot Three-component Mannich Reactions

被引：15

作者：

An Yajie ^{[1
]}

Qin Qian ^{[1
]}

Wang Chuanchuan ^{[1
]}

Tao Jingchao ^{[1
]}

机构：

[1] Zhengzhou Univ, Dept Chem, New Drug Res & Dev Ctr, Zhengzhou 450052, Henan, Peoples R China

来源：

CHINESE JOURNAL OF CHEMISTRY | 2011年 / 29卷 / 07期

基金：

中国国家自然科学基金;

关键词：

isosteviol-amino acid conjugates; asymmetric catalysis; mannich reaction; hydroxyacetone; enantioselectivity; DERIVATIVES; PROLINE; HYDROXYACETONE; ALCOHOLS; SUGARS; SCOPE;

D O I：

10.1002/cjoc.201180272

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Isosteviol-amino acid conjugates were synthesized and used as chiral catalysts for the asymmetric three-component Mannich reaction with hydroxyacetone as donor molecule. Good yields (up to 98%) and excellent stereoselectivities (up to 97: 3 dr and 99% ee) were achieved in a short reaction time. In addition, syn- or anti-configurations of alpha-hydroxy-beta-amino carbonyl compounds were obtained as main products with different chiral catalysts.

引用

页码：1511 / 1517

页数：7

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