IN SILICO STUDIES ON SOME DENGUE VIRAL PROTEINS WITH SELECTED ALLIUM CEPA OIL CONSTITUENTS FROM ROMANIAN SOURCE

被引：4

作者：

Tataringa, Gabriela ^{[1
]}

Spac, Adrian ^{[1
]}

Sathyamurthy, Balasubramanian ^{[2
]}

Zbancioc, Ana Maria ^{[1
]}

机构：

[1] Univ Med & Pharm Grigore T Popa Iasi, Iasi, Romania

[2] Ramaiah Coll Arts Sci & Commerce, Bangalore, Karnataka, India

来源：

FARMACIA | 2020年 / 68卷 / 01期

关键词：

binding interaction; molecular docking; Dengue virus; Allium cepa; ANTIOXIDANT ACTIVITIES; ANTIBACTERIAL;

D O I：

10.31925/farmacia.2020.1.8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Onion (Allium cepa) is a famous spice commonly grown all over the world and consumed in various forms. Onion is a source of various biologically active compounds, such as sulphur compounds and flavonoids, derivatives with a large variety of pharmacological activities including anticancer, antidiabetic, antimicrobial, cardiovascular, antioxidant effects. Onion oil is an important source of sulphur compounds. In this study, the binding efficiency of 11 identified compounds from Allium cepa oil with some selected proteins from Dengue virus through in silico method was done. By virtual screening and docking results, we have found that hexadecanoic acid has the most convenient binding activity for the seven selected proteins.

引用

页码：48 / 55

页数：8

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