Maleimide-functionalized closo-dodecaborate albumin conjugates (MID-AC): Unique ligation at cysteine and lysine residues enables efficient boron delivery to tumor for neutron capture therapy

被引：54

作者：

Kikuchi, Shunsuke ^{[1
]}

Kanoh, Daisuke ^{[2
]}

Sato, Shinichi ^{[1
]}

Sakurai, Yoshinori ^{[3
]}

Suzuki, Minoru ^{[4
]}

Nakamura, Hiroyuki ^{[1
]}

机构：

[1] Tokyo Inst Technol, Inst Innovat Res, Lab Chem & Life Sci, Yokohama, Kanagawa, Japan

[2] Gakushuin Univ, Fac Sci, Dept Chem, Tokyo, Japan

[3] Kyoto Univ, Inst Res Reactor, Dept Radiat Life Sci & Radiat Med Sci, Osaka, Japan

[4] Kyoto Univ, Inst Res Reactor, Particle Radiat Oncol Res Ctr, Osaka, Japan

来源：

JOURNAL OF CONTROLLED RELEASE | 2016年 / 237卷

关键词：

Boron neutron capture therapy (BNCT); Closo-dodecaborate; Albumin modification; Maleimide; Boron delivery system; HUMAN SERUM-ALBUMIN; RECURRENT HEAD; MACROMOLECULAR THERAPEUTICS; METHOTREXATE-ALBUMIN; CANCER; LIPOSOMES; NANOPARTICLES; VEHICLES; TRIAL; ANION;

D O I：

10.1016/j.jconrel.2016.07.017

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Maleimide-conjugating closo-dodecaborate sodium form 5c (MID) synthesized by the nucleophilic ring-opening reaction of closo-dodecaborate-1,4-dioxane complex 2 with tetrabutylammonium (TBA) azide was found to conjugate to free SH of cysteine and lysine residues in BSA under physiological conditions, forming highly boronated BSA that showed high and selective accumulation in tumor and significant tumor growth inhibition in colon 26 tumor-bearing mice subjected to thermal neutron irradiation. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：160 / 167

页数：8

共 40 条

[1] 99Tcm nanocolloid scintigraphy:: a reliable way to detect active joint disease in patients with peripheral joint pain [J].

Adams, BK ;

Al Attia, HM ;

Khadim, RA ;

Al Haider, ZY .

NUCLEAR MEDICINE COMMUNICATIONS, 2001, 22 (03) :315-318

[2] First clinical case of boron neutron capture therapy for head and neck malignancies using 18F-BPA pet [J].

Aihara, Teruhito ;

Hiratsuka, Junichi ;

Morita, Norimasa ;

Uno, Masako ;

Sakurai, Yoshinori ;

Maruhashi, Akira ;

Ono, Koji ;

Harada, Tamotsu .

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, 2006, 28 (09) :850-855

[3] Current status of boron neutron capture therapy of high grade gliomas and recurrent head and neck cancer [J].

Barth, Rolf F. ;

Vicente, M. Graca H. ;

Harling, Otto K. ;

Kiger, W. S., III ;

Riley, Kent J. ;

Binns, Peter J. ;

Wagner, Franz M. ;

Suzuki, Minoru ;

Aihara, Teruhito ;

Kato, Itsuro ;

Kawabata, Shinji .

RADIATION ONCOLOGY, 2012, 7

[4] Prospects in Boron Neutron Capture Therapy of Brain Tumors [J].

Byvaltsev, Vadim ;

Kanygin, Vladimir ;

Belykh, Eugeny ;

Taskaev, Sergey .

WORLD NEUROSURGERY, 2012, 78 (1-2) :8-9

[5]

Dhabuwala Atul, 2005, BMC Nucl Med, V5, P7, DOI 10.1186/1471-2385-5-7

[6] Impact of albumin on drug delivery - New applications on the horizon [J].

Elsadek, Bakheet ;

Kratz, Felix .

JOURNAL OF CONTROLLED RELEASE, 2012, 157 (01) :4-28

[7] Human serum albumin: From bench to bedside [J].

Fanali, Gabriella ;

di Masi, Alessandra ;

Trezza, Viviana ;

Marino, Maria ;

Fasano, Mauro ;

Ascenzi, Paolo .

MOLECULAR ASPECTS OF MEDICINE, 2012, 33 (03) :209-290

[8] Significantly Longer Progression-Free Survival With nab-Paclitaxel Compared With Docetaxel As First-Line Therapy for Metastatic Breast Cancer [J].

Gradishar, William J. ;

Krasnojon, Dimitry ;

Cheporov, Sergey ;

Makhson, Anatoly N. ;

Manikhas, Georgiy M. ;

Clawson, Alicia ;

Bhar, Paul .

JOURNAL OF CLINICAL ONCOLOGY, 2009, 27 (22) :3611-3619

[9] Michael Addition Reactions for the Modification of Gold Nanoparticles Facilitated by Hyperbaric Conditions [J].

Hartlen, Kurtis D. ;

Ismaili, Hossein ;

Zhu, Jun ;

Workentin, Mark S. .

LANGMUIR, 2012, 28 (01) :864-871

[10]

Hartung G, 1999, CLIN CANCER RES, V5, P753

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