Extended-Spectrum β-Lactamase Genes of Escherichia coli in Chicken Meat and Humans, the Netherlands

被引:450
作者
Overdevest, Ilse [2 ]
Willemsen, Ina
Rijnsburger, Martine [3 ]
Eustace, Andrew [4 ]
Xu, Li [4 ]
Hawkey, Peter [4 ,5 ]
Heck, Max [6 ]
Savelkoul, Paul [3 ]
Vandenbroucke-Grauls, Christina [3 ]
van der Zwaluw, Kim [6 ]
Huijsdens, Xander [6 ]
Kluytmans, Jan [1 ,2 ,3 ]
机构
[1] Amphia Hosp, Lab Microbiol & Infect Control, NL-4800 RK Breda, Netherlands
[2] St Elizabeth Hosp, Tilburg, Netherlands
[3] Univ Med Ctr, Amsterdam, Netherlands
[4] Heart England Natl Hlth Serv Fdn Trust, Birmingham, W Midlands, England
[5] Univ Birmingham, Birmingham, W Midlands, England
[6] Natl Inst Publ Hlth & Environm Protect, NL-3720 BA Bilthoven, Netherlands
关键词
CTX-M; ENTEROBACTERIACEAE; RESISTANCE; PREVALENCE; EMERGENCE;
D O I
10.3201/eid1707.110209
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
We determined the prevalence and characteristics of extended-spectrum beta-lactamase (ESBL) genes of Enterobacteriaceae in retail chicken meat and humans in the Netherlands. Raw meat samples were obtained, and simultaneous cross-sectional surveys of fecal carriage were performed in 4 hospitals in the same area. Human blood cultures from these hospitals that contained ESBL genes were included. A high prevalence of ESBL genes was found in chicken meat (79.8%). Genetic analysis showed that the predominant ESBL genes in chicken meat and human rectal swab specimens were identical. These genes were also frequently found in human blood culture isolates. Typing results of Escherichia coli strains showed a high degree of similarity with strains from meat and humans. These findings suggest that the abundant presence of ESBL genes in the food chain may have a profound effect on future treatment options for a wide range of infections caused by gram-negative bacteria.
引用
收藏
页码:1216 / 1222
页数:7
相关论文
共 32 条
  • [1] al Naiemi N, 2008, TIJDSCHRIFT MEDISCHE, V2, P23
  • [2] [Anonymous], 2008, Monitoring of Antimicrobial Resistance and Antibiotic Usage in Animals in the Netherlands (MARAN)
  • [3] Prevalence and spread of extended-spectrum β-lactamase-producing Enterobacteriaceae in Europe
    Canton, R.
    Novais, A.
    Valverde, A.
    Machado, E.
    Peixe, L.
    Baquero, F.
    Coque, T. M.
    [J]. CLINICAL MICROBIOLOGY AND INFECTION, 2008, 14 : 144 - 153
  • [4] Resistance Plasmid Families in Enterobacteriaceae
    Carattoli, Alessandra
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2009, 53 (06) : 2227 - 2238
  • [5] Coque TM, 2008, EURO SURVEILL, V13
  • [6] The relationship between antimicrobial resistance and patient outcomes: Mortality, length of hospital stay, and health care costs
    Cosgrove, SE
    [J]. CLINICAL INFECTIOUS DISEASES, 2006, 42 : S82 - S89
  • [7] Extended-spectrum and CMY-type β-lactamase-producing Escherichia coli in clinical samples and retail meat from Pittsburgh, USA and Seville, Spain
    Doi, Y.
    Paterson, D. L.
    Egea, P.
    Pascual, A.
    Lopez-Cerero, L.
    Navarro, M. D.
    Adams-Haduch, J. M.
    Qureshi, Z. A.
    Sidjabat, H. E.
    Rodriguez-Bano, J.
    [J]. CLINICAL MICROBIOLOGY AND INFECTION, 2010, 16 (01) : 33 - 38
  • [8] CTX-M-producing Escherichia coli in a maternity ward: a likely community importation and evidence of mother-to-neonate transmission
    Dubois, Veronique
    De Barbeyrac, Bertille
    Rogues, Anne-Marie
    Arpin, Corinne
    Coulange, Laure
    Andre, Catherine
    M'Zali, Fatima
    Megraud, Francis
    Quentin, Claudine
    [J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2010, 65 (07) : 1368 - 1371
  • [9] The growing threat of foodborne bacterial enteropathogens of animal origin
    DuPont, Herbert L.
    [J]. CLINICAL INFECTIOUS DISEASES, 2007, 45 (10) : 1353 - 1361
  • [10] Ceftiofur Resistance in Salmonella enterica Serovar Heidelberg from Chicken Meat and Humans, Canada
    Dutil, Lucie
    Irwin, Rebecca
    Finley, Rita
    Ng, Lai King
    Avery, Brent
    Boerlin, Patrick
    Bourgault, Anne-Marie
    Cole, Linda
    Daignault, Danielle
    Desruisseau, Andrea
    Demczuk, Walter
    Hoang, Linda
    Horsman, Greg B.
    Ismail, Johanne
    Jamieson, Frances
    Maki, Anne
    Pacagnella, Ana
    Pillai, Dylan R.
    [J]. EMERGING INFECTIOUS DISEASES, 2010, 16 (01) : 48 - 54