Extended-Spectrum β-Lactamase Genes of Escherichia coli in Chicken Meat and Humans, the Netherlands

被引：457

作者：

Overdevest, Ilse ^{[2
]}

Willemsen, Ina

Rijnsburger, Martine ^{[3
]}

Eustace, Andrew ^{[4
]}

Xu, Li ^{[4
]}

Hawkey, Peter ^{[4
,5
]}

Heck, Max ^{[6
]}

Savelkoul, Paul ^{[3
]}

Vandenbroucke-Grauls, Christina ^{[3
]}

van der Zwaluw, Kim ^{[6
]}

Huijsdens, Xander ^{[6
]}

Kluytmans, Jan ^{[1
,2
,3
]}

机构：

[1] Amphia Hosp, Lab Microbiol & Infect Control, NL-4800 RK Breda, Netherlands

[2] St Elizabeth Hosp, Tilburg, Netherlands

[3] Univ Med Ctr, Amsterdam, Netherlands

[4] Heart England Natl Hlth Serv Fdn Trust, Birmingham, W Midlands, England

[5] Univ Birmingham, Birmingham, W Midlands, England

[6] Natl Inst Publ Hlth & Environm Protect, NL-3720 BA Bilthoven, Netherlands

来源：

EMERGING INFECTIOUS DISEASES | 2011年 / 17卷 / 07期

关键词：

CTX-M; ENTEROBACTERIACEAE; RESISTANCE; PREVALENCE; EMERGENCE;

D O I：

10.3201/eid1707.110209

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We determined the prevalence and characteristics of extended-spectrum beta-lactamase (ESBL) genes of Enterobacteriaceae in retail chicken meat and humans in the Netherlands. Raw meat samples were obtained, and simultaneous cross-sectional surveys of fecal carriage were performed in 4 hospitals in the same area. Human blood cultures from these hospitals that contained ESBL genes were included. A high prevalence of ESBL genes was found in chicken meat (79.8%). Genetic analysis showed that the predominant ESBL genes in chicken meat and human rectal swab specimens were identical. These genes were also frequently found in human blood culture isolates. Typing results of Escherichia coli strains showed a high degree of similarity with strains from meat and humans. These findings suggest that the abundant presence of ESBL genes in the food chain may have a profound effect on future treatment options for a wide range of infections caused by gram-negative bacteria.

引用

页码：1216 / 1222

页数：7

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