Novel platinum(II) complexes with dipyridyl containing chelating ligands and their products with the model nucleobases 1-methylthymine and 1-methyluracil

被引：0
作者：
Puscasu, I
Mock, C
Rauterkus, M
Röndigs, A
Tallen, G
Gangopadhyay, S
Wolff, JEA
Krebs, B
机构：
[1] Univ Munster, Inst Anorgan Chem, D-48149 Munster, Germany
[2] Univ Calgary, Fac Med, Canc Biol Res Grp, Calgary, AB, Canada
来源：
ZEITSCHRIFT FUR ANORGANISCHE UND ALLGEMEINE CHEMIE | 2001年 / 627卷 / 06期
关键词：
platinum complexes; antitumor activity; nucleobases; crystal structures;
D O I：
10.1002/1521-3749(200106)627:6<1292::AID-ZAAC1292>3.0.CO;2-P
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
The reactions of [Pt(dpma)(H2O)(2)](2+) (dpma = 2,2 ' -dipyridylmethylamine) and [Pt(dpk)(H2O)(2)](2+) (dpk = 2,2 ' -dipyridylketone) with the model nucleobases 1-methylthymine (1-MeT) and 1-methyluracil (1-MeY) were studied. Reaction products were characterized by Pt-195 NMR spectroscopy and by X-ray structure analysis. The symmetric dpma and dpk diaqua complexes form dinuclear complexes with 1-methylthymine, acting as secondary bridging ligand via its N3 and O4 donor atoms. [Pt-2(dpma)(2)(1-MeT)(2)](ClO4)(2).H2O (5) and [Pt-2(dpk)(dpk . H2O)(1-MeT)(2)](PF6)(2) . 4H(2)O (6) both show a head-to-head arrangement. Biological tests show a significant in vitro antitumor activity of [Pt(dpk)Cl-2] against the human glioma cell line U87.
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页码：1292 / 1298
页数：7
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