Novel platinum(II) complexes with dipyridyl containing chelating ligands and their products with the model nucleobases 1-methylthymine and 1-methyluracil

被引：0

作者：

Puscasu, I

Mock, C

Rauterkus, M

Röndigs, A

Tallen, G

Gangopadhyay, S

Wolff, JEA

Krebs, B

机构：

[1] Univ Munster, Inst Anorgan Chem, D-48149 Munster, Germany

[2] Univ Calgary, Fac Med, Canc Biol Res Grp, Calgary, AB, Canada

来源：

ZEITSCHRIFT FUR ANORGANISCHE UND ALLGEMEINE CHEMIE | 2001年 / 627卷 / 06期

关键词：

platinum complexes; antitumor activity; nucleobases; crystal structures;

D O I：

10.1002/1521-3749(200106)627:6<1292::AID-ZAAC1292>3.0.CO;2-P

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The reactions of [Pt(dpma)(H2O)(2)](2+) (dpma = 2,2 ' -dipyridylmethylamine) and [Pt(dpk)(H2O)(2)](2+) (dpk = 2,2 ' -dipyridylketone) with the model nucleobases 1-methylthymine (1-MeT) and 1-methyluracil (1-MeY) were studied. Reaction products were characterized by Pt-195 NMR spectroscopy and by X-ray structure analysis. The symmetric dpma and dpk diaqua complexes form dinuclear complexes with 1-methylthymine, acting as secondary bridging ligand via its N3 and O4 donor atoms. [Pt-2(dpma)(2)(1-MeT)(2)](ClO4)(2).H2O (5) and [Pt-2(dpk)(dpk . H2O)(1-MeT)(2)](PF6)(2) . 4H(2)O (6) both show a head-to-head arrangement. Biological tests show a significant in vitro antitumor activity of [Pt(dpk)Cl-2] against the human glioma cell line U87.

引用

页码：1292 / 1298

页数：7

共 22 条

[1] Synthesis, crystal structure, antitumor activity, and DNA-binding properties of the new active platinum compound (bis(N-methylimidazol-2-yl)carbinol)dichloroplatinum(II), lacking a NH moiety, and of the inactive analog dichloro(N-1, N-1'-dimethyl-2,2'-biimidazole)platinum(II) [J].