miRTarBase update 2022: an informative resource for experimentally validated miRNA-target interactions

被引：602

作者：

Huang, Hsi-Yuan ^{[1
,2
,3
]}

Lin, Yang-Chi-Dung ^{[1
,2
,3
]}

Cui, Shidong ^{[2
,3
]}

Huang, Yixian ^{[2
,3
]}

Tang, Yun ^{[2
,3
]}

Xu, Jiatong ^{[2
,3
]}

Bao, Jiayang ^{[4
]}

Li, Yulin ^{[2
,3
]}

Wen, Jia ^{[2
,3
]}

Zuo, Huali ^{[2
,3
,5
]}

Wang, Weijuan ^{[2
,3
]}

Li, Jing ^{[2
,3
]}

Ni, Jie ^{[3
]}

Ruan, Yini ^{[3
]}

Li, Liping ^{[3
]}

Chen, Yidan ^{[2
,3
]}

Xie, Yueyang ^{[3
]}

Zhu, Zihao ^{[2
,3
]}

Cai, Xiaoxuan ^{[2
,3
]}

Chen, Xinyi ^{[2
,3
]}

Yao, Lantian ^{[3
,6
]}

Chen, Yigang ^{[2
,3
]}

Luo, Yijun ^{[2
,3
]}

LuXu, Shupeng ^{[2
,3
]}

Luo, Mengqi ^{[2
,3
]}

Chiu, Chih-Min ^{[2
,3
]}

Ma, Kun ^{[3
]}

Zhu, Lizhe ^{[2
,3
]}

Cheng, Gui-Juan ^{[2
,3
]}

Bai, Chen ^{[2
,3
]}

Chiang, Ying-Chih ^{[7
]}

Wang, Liping ^{[8
]}

Wei, Fengxiang ^{[1
,9
,10
]}

Lee, Tzong-Yi ^{[2
,3
]}

Huang, Hsien-Da ^{[1
,2
,3
]}

机构：

[1] Longgang Dist Matern & Child Healthcare Hosp Shen, Genet Lab, Shenzhen 518172, Guangdong, Peoples R China

[2] Chinese Univ Hong Kong, Sch Life & Hlth Sci, Shenzhen 518172, Guangdong, Peoples R China

[3] Chinese Univ Hong Kong, Warshel Inst Computat Biol, Shenzhen 518172, Guangdong, Peoples R China

[4] Univ Calif San Diego, Div Biol Sci, Sect Bioinformat, San Diego, CA 92093 USA

[5] Univ Sci & Technol China, Sch Comp Sci & Technol, Hefei 230027, Peoples R China

[6] Chinese Univ Hong Kong, Sch Sci & Engn, Shenzhen 518172, Guangdong, Peoples R China

[7] Chinese Univ Hong Kong, Sch Life & Hlth Sci, Kobilka Inst Innovat Drug Discovery, Shenzhen 518172, Guangdong, Peoples R China

[8] Shenzhen Univ, Shenzhen Peoples Hosp 2, Dept Reprod Med Ctr, Affiliated Hosp 1, Shenzhen 518035, Guangdong, Peoples R China

[9] Jiamusi Univ, Dept Cell Biol, Jiamusi 154007, Heilongjiang, Peoples R China

[10] China Med Univ, Shenzhen Childrens Hosp, Shenzhen 518172, Guangdong, Peoples R China

来源：

NUCLEIC ACIDS RESEARCH | 2022年 / 50卷 / D1期

基金：

中国国家自然科学基金;

关键词：

MICRORNA EXPRESSION; CANCER; SERUM; RNA; DIAGNOSIS; MECHANISMS; BIOMARKERS; PATTERNS; EXOSOMES; GENOMICS;

D O I：

10.1093/nar/gkab1079

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

MicroRNAs (miRNAs) are noncoding RNAs with 18-26 nucleotides; they pair with target mRNAs to regulate gene expression and produce significant changes in various physiological and pathological processes. In recent years, the interaction between miRNAs and their target genes has become one of the mainstream directions for drug development. As a large-scale biological database that mainly provides miRNA-target interactions (MTIs) verified by biological experiments, miRTarBase has undergone five revisions and enhancements. The database has accumulated >2 200 449 verified MTIs from 13 389 manually curated articles and CLIP-seq data. An optimized scoring system is adopted to enhance this update's critical recognition of MTI-related articles and corresponding disease information. In addition, single-nucleotide polymorphisms and disease-related variants related to the binding efficiency of miRNA and target were characterized in miRNAs and gene 3'untranslated regions. miRNA expression profiles across extracellular vesicles, blood and different tissues, including exosomal miRNAs and tissue-specific miRNAs, were integrated to explore miRNA functions and biomarkers. For the user interface, we have classified attributes, including RNA expression, specific interaction, protein expression and biological function, for various validation experiments related to the role of miRNA. We also used seed sequence information to evaluate the binding sites of miRNA. In summary, these enhancements render miRTarBase as one of the most research-amicable MTI databases that contain comprehensive and experimentally verified annotations. The newly updated version of miRTarBase is now available at https://miRTarBase.cuhk.edu.cn/.

引用

页码：D222 / D230

页数：9

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