Comparison of preventive effect of sildenafil and therapeutic effect of sildenafil treatment in rats with monocrotaline-induced pulmonary arterial hypertension

被引：4

作者：

Yoshiyuki, Rieko ^{[1
]}

Fukushima, Ryuji ^{[1
]}

Tanaka, Ryo ^{[1
]}

Machida, Noboru ^{[2
]}

机构：

[1] Tokyo Univ Agr & Technol, Dept Vet Surg, Fac Agr, 3-5-8 Saiwai Cho, Fuchu, Tokyo 1838509, Japan

[2] Tokyo Univ Agr & Technol, Dept Vet Clin Oncol, Fac Agr, 3-5-8 Saiwai Cho, Fuchu, Tokyo 1838509, Japan

来源：

JOURNAL OF VETERINARY MEDICAL SCIENCE | 2016年 / 78卷 / 10期

关键词：

echocardiography; monocrotaline; pulmonary hypertension; rat; sildenafil; RHO-KINASE INHIBITOR; HEART-FAILURE; SURVIVAL; HEMODYNAMICS; COMBINATION; GUIDELINES; MODEL;

D O I：

10.1292/jvms.15-0544

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

This study aimed to investigate the potential effects of sildenafil on pulmonary hypertension (PH) in the monocrotaline (MCT)-induced PH rat. Twenty-four, 12-week-old, male Sprague-Dawley rats were injected with MCT or saline solution. After injection of MCT, rats received oral sildenafil immediately (early-phase treatment group: E group), 4 weeks after injection (late-phase treatment group: L group) or no treatment (MCT group) until 6 weeks after injection. Serial echocardiography and right ventricular systolic pressure (RVSP) measurements via a cardiac catheter were performed. RVSP was reduced in the E and L groups compared with the MCT group. Echocardiography indicated that sildenafil therapy prevents an increase in RVSP and preserves diastolic function, and this effect is not dependent on timing of initiation of therapy.

引用

页码：1607 / 1610

页数：4

共 29 条

[1] Long-term treatment with a Rho-kinase inhibitor improves monocrotaline-induced fatal pulmonary hypertension in rats [J].

Abe, K ;

Shimokawa, H ;

Morikawa, K ;

Uwatoku, T ;

Oi, K ;

Matsumoto, Y ;

Hattori, T ;

Nakashima, Y ;

Kaibuchi, K ;

Sueishi, K ;

Takeshita, A .

CIRCULATION RESEARCH, 2004, 94 (03) :385-393

[2] Acute effects of sildenafil and dobutamine in the hypertrophic and failing right heart in vivo [J].

Andersen, Asger ;

Nielsen, Jan M. ;

Rasalingam, Sivagowry ;

Sloth, Erik ;

Nielsen-Kudsk, Jens Erik .

PULMONARY CIRCULATION, 2013, 3 (03) :599-610

[3] Noninvasive assessment of acute cardiopulmonary effects of an oral single dose of sildenafil in patients with idiopathic pulmonary hypertension [J].

Behzadnia, Neda ;

Najafizadeh, Katayoun ;

Sharif-Kashani, Babak ;

Dameshghi, Davoud Oulad ;

Shahabi, Payman .

HEART AND VESSELS, 2010, 25 (04) :313-318

[4] Early inflammatory response during the development of right ventricular heart failure in a rat model [J].

Campian, Maria E. ;

Hardziyenka, Maxim ;

de Bruin, Kora ;

van Eck-Smit, Berthe L. F. ;

de Bakker, Jacques M. T. ;

Verberne, Hein J. ;

Tan, Hanno L. .

EUROPEAN JOURNAL OF HEART FAILURE, 2010, 12 (07) :653-658

[5] Use of sildenafil (Viagra) in patients with cardiovascular disease [J].

Cheitlin, MD ;

Hutter, AM ;

Brindis, RG ;

Ganz, P ;

Kaul, S ;

Russell, RO ;

Zusman, RM ;

Forrester, JS ;

Douglas, PS ;

Faxon, DP ;

Fisher, JD ;

Gibbons, RJ ;

Halperin, JL ;

Hutter, AM ;

Hochman, JS ;

Kaul, S ;

Weintraub, WS ;

Winters, WL ;

Wolk, MJ .

CIRCULATION, 1999, 99 (01) :168-177

[6]

Clozel M, 2006, EXP BIOL MED, V231, P967

[7] Improved Survival Among Patients With Eisenmenger Syndrome Receiving Advanced Therapy for Pulmonary Arterial Hypertension [J].

Dimopoulos, Konstantinos ;

Inuzuka, Ryo ;

Goletto, Sara ;

Giannakoulas, Georgios ;

Swan, Lorna ;

Wort, Stephen J. ;

Gatzoulis, Michael A. .

CIRCULATION, 2010, 121 (01) :20-25

[8]

Efthimiadis G K, 2002, Eur J Echocardiogr, V3, P143, DOI 10.1053/euje.2001.0105

[9] Combination Therapy With Fasudil and Sildenafil Ameliorates Monocrotaline-Induced Pulmonary Hypertension and Survival in Rats [J].

Elias-Al-Mamun, Md ;

Satoh, Kimio ;

Tanaka, Shin-ichi ;

Shimizu, Toru ;

Nergui, Suvd ;

Miyata, Satoshi ;

Fukumoto, Yoshihiro ;

Shimokawa, Hiroaki .

CIRCULATION JOURNAL, 2014, 78 (04) :967-976

[10] Sildenafil citrate therapy for pulmonary arterial hypertension [J].

Galiè, N ;

Ghofrani, HA ;

Torbicki, A ;

Barst, RJ ;

Rubin, LJ ;

Badesch, D ;

Fleming, T ;

Parpia, T ;

Burgess, G ;

Branzi, A ;

Grimminger, F ;

Kurzyna, M ;

Simonneau, G .

NEW ENGLAND JOURNAL OF MEDICINE, 2005, 353 (20) :2148-2157

← 1 2 3 →