Isoquinoline alkaloid dimers with dopamine D1 receptor activities from Menispermum dauricum DC

被引：5
|
作者：
Wei, Hong-Li [1 ,2 ]
Han, Yang [1 ,2 ]
Zhou, Han [1 ]
Hou, Tao [1 ]
Yao, Yu-Min [1 ]
Wen, Chun-Mei [3 ]
Wang, Chao-Ran [1 ]
Wang, Ji-Xia [1 ]
Shen, Ai-Jin [1 ]
Zhang, Xiu-Li [4 ]
Li, Hao [3 ]
Liu, Yan-Fang [1 ,3 ]
机构：
[1] Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
[3] Ganjiang Chinese Med Innovat Ctr, Nanchang 330000, Jiangxi, Peoples R China
[4] Soochow Univ, Coll Pharmaceut Sci, Suzhou 215006, Peoples R China
来源：
PHYTOCHEMISTRY | 2022年 / 194卷
关键词：
Menispermum dauricum DC; Menispermaceae; Dimeric isoquinoline alkaloids; Electronic circular dichroism; D1 antagonistic activity;
D O I：
10.1016/j.phytochem.2021.113015
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A phytochemical investigation on chemical constituents from the rhizomes of Menispermum dauricum DC. identified eight undescribed dimeric alkaloids with structurally diverse monomeric isoquinoline. Alkaloid structures were elucidated by a combination of spectroscopic data analyses and time-dependent density functional theory (TDDFT) ECD calculation. The isolates were evaluated for inhibitory effect on dopamine D1 receptor and compound 1 exhibited potent D1 receptor antagonistic activity with an IC50 value of 8.4 +/- 2.0 mu M.
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页数：9
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