Isoquinoline alkaloid dimers with dopamine D1 receptor activities from Menispermum dauricum DC

被引：5

作者：

Wei, Hong-Li ^{[1
,2
]}

Han, Yang ^{[1
,2
]}

Zhou, Han ^{[1
]}

Hou, Tao ^{[1
]}

Yao, Yu-Min ^{[1
]}

Wen, Chun-Mei ^{[3
]}

Wang, Chao-Ran ^{[1
]}

Wang, Ji-Xia ^{[1
]}

Shen, Ai-Jin ^{[1
]}

Zhang, Xiu-Li ^{[4
]}

Li, Hao ^{[3
]}

Liu, Yan-Fang ^{[1
,3
]}

机构：

[1] Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China

[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

[3] Ganjiang Chinese Med Innovat Ctr, Nanchang 330000, Jiangxi, Peoples R China

[4] Soochow Univ, Coll Pharmaceut Sci, Suzhou 215006, Peoples R China

来源：

PHYTOCHEMISTRY | 2022年 / 194卷

关键词：

Menispermum dauricum DC; Menispermaceae; Dimeric isoquinoline alkaloids; Electronic circular dichroism; D1 antagonistic activity;

D O I：

10.1016/j.phytochem.2021.113015

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A phytochemical investigation on chemical constituents from the rhizomes of Menispermum dauricum DC. identified eight undescribed dimeric alkaloids with structurally diverse monomeric isoquinoline. Alkaloid structures were elucidated by a combination of spectroscopic data analyses and time-dependent density functional theory (TDDFT) ECD calculation. The isolates were evaluated for inhibitory effect on dopamine D1 receptor and compound 1 exhibited potent D1 receptor antagonistic activity with an IC50 value of 8.4 +/- 2.0 mu M.

引用

页数：9

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