Leishmanicidal phenolic compounds derived from Dalbergia cultrata

被引：10

作者：

Mori-Yasumoto, Kanami ^{[1
]}

Hashimoto, Yukihiro ^{[1
]}

Agatsuma, Yutaka ^{[2
]}

Fuchino, Hiroyuki ^{[3
]}

Yasumoto, Ko ^{[4
]}

Shirota, Osamu ^{[1
]}

Satake, Motoyoshi ^{[2
,5
]}

Sekita, Setsuko ^{[1
,5
]}

机构：

[1] Tokushima Bunri Univ, Kagawa Sch Pharmaceut Sci, Sanuki, Kagawa, Japan

[2] Ochanomizu Univ, Inst Environm Sci & Life, Bunkyo Ku, Tokyo, Japan

[3] Natl Inst Biomed Innovat Hlth & Nutr, Tsukuba, Ibaraki, Japan

[4] Kitasato Univ, Sch Marine Biosci, Sagamihara, Kanagawa, Japan

[5] Showa Pharmaceut Univ, Machida, Tokyo, Japan

来源：

NATURAL PRODUCT RESEARCH | 2021年 / 35卷 / 23期

关键词：

Leishmania; Dalbergia cultrata; yin-daik; Myanmar; leguminosae; CONSTITUENTS; NEOFLAVANOIDS; NEOFLAVONOIDS; HEARTWOOD;

D O I：

10.1080/14786419.2020.1744140

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Leishmaniasis is a protozoan tropical infection that is estimated to be more than 0.3 million new cases occur annually worldwide. A novel phenolic compound, cultratin A (1), was isolated as a leishmanicidal constituent from the timber of Dalbergia cultrata, along with three known neoflavanoids (2, 3, 4), two benzofurans (5, 6), and two phenolic compounds (7, 8). Their structures were determined using spectral methods. Among them, a new compound (1) and 4-(S)-methoxydalbergione (2) showed effective leishmanicidal activities (IC50: 2.0 and 2.6 mu M, respectively), while compound 8 showed moderate activity (IC50: 11 mu M). The cytotoxicity of compounds 1 and 2 was also weaker than that of the other compounds.

引用

页码：4907 / 4915

页数：9

共 19 条

[1] New coumestan and coumaronochromone derivatives from Dalbergia boehmii Taub. (Fabaceae) [J].

Abdou, Jean Pierre ;

Momeni, Jean ;

Adhikari, Achyut ;

Tsabang, Nole ;

Tchinda, Alembert T. ;

Choudhary, Muhammad I. ;

Nkengfack, Augustin E. .

PHYTOCHEMISTRY LETTERS, 2017, 21 :109-113

[2] CONSTITUTION OF DALBERGIN .4. A NOVEL TRANSFORMATION OF O-METHYLDALBERGIN [J].

AHLUWALIA, VK ;

MEHTA, AC ;

SESHADRI, TR .

TETRAHEDRON, 1958, 4 (3-4) :271-274

[3] ESTIMATION OF POPULATION AT RISK OF INFECTION AND NUMBER OF CASES OF LEISHMANIASIS [J].

ASHFORD, RW ;

DESJEUX, P ;

DERAADT, P .

PARASITOLOGY TODAY, 1992, 8 (03) :104-105

[4] A Review on the Phytochemistry, Medicinal Properties and Pharmacological Activities of 15 Selected Myanmar Medicinal Plants [J].

Aye, Mya Mu ;

Aung, Hnin Thanda ;

Sein, Myint Myint ;

Armijos, Chabaco .

MOLECULES, 2019, 24 (02)

[5] The pharmacology of leishmaniasis [J].

Balaña-Fouce, R ;

Reguera, RM ;

Cubría, JC ;

Ordóñez, D .

GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM, 1998, 30 (04) :435-443

[6] An isoflavanoid-neoflavonoid and an O-methylated isoflavone from the heartwood of Dalbergia nitidula [J].

Bekker, M ;

Malan, E ;

Steenkamp, JA ;

Brandt, EV .

PHYTOCHEMISTRY, 2002, 59 (04) :415-418

[7] Neoflavonoids from Dalbergia odorifera [J].

Chan, SC ;

Chang, YS ;

Kuo, SC .

PHYTOCHEMISTRY, 1997, 46 (05) :947-949

[8] Fast and long acting neoflavonoids dalbergin isolated from Dalbergia sissoo heartwood is osteoprotective in ovariectomized model of osteoporosis: Osteoprotective effect of Dalbergin [J].

Choudhary, Dharmendra ;

Kushwaha, Priyanka ;

Gautam, Jyoti ;

Kumar, Padam ;

Verma, Ashwani ;

Kumar, Avinash ;

Maurya, Saransh Wales ;

Siddiqui, Ibadur Rahman ;

Mishra, Prabhat Ranjan ;

Maurya, Rakesh ;

Trivedi, Ritu .

BIOMEDICINE & PHARMACOTHERAPY, 2016, 83 :942-957

[9] NEOFLAVANOIDS [J].

DONNELLY, DM .

PHYTOCHEMISTRY, 1972, 11 (02) :862-&

[10] Two new aromatic constituents from the rootwood of Aeschynomene mimosifolia [J].

Fullas, F ;

Kornberg, LJ ;

Wani, MC ;

Wall, ME ;

Farnsworth, NR ;

Chagwedera, TE ;

Kinghorn, AD .

JOURNAL OF NATURAL PRODUCTS, 1996, 59 (02) :190-192

← 1 2 →