Alkaloids derived from genus Veratrum and Peganum of Mongolian origin as multidrug resistance inhibitors of cancer cells

被引：26

作者：

Ivanova, Antoaneta ^{[1
]}

Serly, Julianna ^{[2
]}

Christov, Veselin ^{[1
]}

Stamboliyska, Bistra ^{[1
]}

Molnar, Joseph ^{[2
]}

机构：

[1] Bulgarian Acad Sci, Ctr Phytochem, Inst Organ Chem, BU-1113 Sofia, Bulgaria

[2] Univ Szeged, Dept Med Microbiol & Immunobiol, H-6720 Szeged, Hungary

来源：

FITOTERAPIA | 2011年 / 82卷 / 04期

关键词：

Veratrum lobelianum; Veratrum nigrum; Peganum nigellastrum; Steroidal alkaloids; Multidrug resistance; MDR1; P-GLYCOPROTEIN; STEROIDAL ALKALOIDS; IN-VITRO; REVERSAL; EXPRESSION; TRANSPORT; DENSITY;

D O I：

10.1016/j.fitote.2011.01.015

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Alkaloids comprise one of the largest groups of plant secondary metabolites including vinca alkaloids. The ability of six alkaloids from Veratrum lobelianum, one from Veratrum nigrum and three from Peganum nigellastrum to modify transport activity of MDR1 was studied. Flow-cytometry in a multidrug-resistant human MDR1-gene-transfected mouse lymphoma cells (L5178Y) was applied. The inhibition of multidrug resistance was investigated by measuring the accumulation of rhodamine-123 in cancer cells. Veralosinine and veranigrine were the most effective resistance modifiers. In a checkerboard method veralosinine and veranigrine enhanced the antiproliferative effects of doxorubicin on MDR cells in combination. The structure-activity relationships were discussed. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：570 / 575

页数：6

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