CINSARC signature as a prognostic marker for clinical outcome in sarcomas and beyond

被引：31

作者：

Chibon, Frederic ^{[1
,2
]}

Lesluyes, Tom ^{[1
,3
,4
]}

Valentin, Thibaud ^{[1
,5
]}

Le Guellec, Sophie ^{[1
,2
]}

机构：

[1] INSERM, U1037, CRCT, Toulouse, France

[2] Inst Claudius Regaud, Dept Pathol, Toulouse, France

[3] Univ Bordeaux, Bordeaux, France

[4] Inst Claudius Regaud, Toulouse, France

[5] Inst Claudius Regaud, Dept Med Oncol, Toulouse, France

来源：

GENES CHROMOSOMES & CANCER | 2019年 / 58卷 / 02期

关键词：

chromosome instability; CINSARC; prognosis; sarcoma; SOFT-TISSUE SARCOMAS; GENE-EXPRESSION; CHROMOSOMAL INSTABILITY; TARGET; ANEUPLOIDY; KINASE; IDENTIFICATION; SPECIFICITY; INTEGRATION; DEFINITION;

D O I：

10.1002/gcc.22703

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Prognostication is a key issue for sarcoma patients' care as it triggers the therapeutic approach including chemotherapy, which is still not standard for localized patients. Current prognostic evaluation, based on the FNCLCC grading system, has recently been improved by the CINSARC signature outperforming histology-based grading system by identifying high-risk patients in every grade, even in those considered as low. CINSARC is an expression-based signature related to mitosis and chromosome integrity with prognostic value in a wide range of cancers additional to sarcoma. First developed with frozen material, CINSARC is now coupled with NanoString technology allowing evaluation from FFPE blocks used in clinical practice. Consequently, CINSARC is currently evaluated in clinical trials with a dual objective of demonstrating the benefit of chemotherapy in sarcoma patients and testing its response prediction. Considering its overarching value in oncology, its development is welcome in any cancers where the prognostication needs to be improved.

引用

页码：124 / 129

页数：6

共 50 条

[21] Heterogeneity in sarcoma cell lines reveals enhanced motility of tetraploid versus diploid cells [J].

Jemaa, Mohamed ;

Abdallah, Samer ;

Lledo, Gwendaline ;

Perrot, Gaelle ;

Lesluyes, Tom ;

Teyssier, Catherine ;

Roux, Pierre ;

van Dijk, Juliette ;

Chibon, Frederic ;

Abrieu, Ariane ;

Morin, Nathalie .

ONCOTARGET, 2017, 8 (10) :16669-16689

[22] E2F1-Mediated Induction of NFYB Attenuates Apoptosis via Joint Regulation of a Pro-Survival Transcriptional Program [J].

Jiang, Xiaolei ;

Nevins, Joseph Roy ;

Shats, Igor ;

Chi, Jen-Tsan .

PLOS ONE, 2015, 10 (06)

[23] Chromosome Instability Accounts for Reverse Metastatic Outcomes of Pediatric and Adult Synovial Sarcomas [J].

Lagarde, Pauline ;

Przybyl, Joanna ;

Brulard, Celine ;

Perot, Gaelle ;

Pierron, Gaelle ;

Delattre, Olivier ;

Sciot, Raf ;

Wozniak, Agnieszka ;

Schoffski, Patrick ;

Terrier, Philippe ;

Neuville, Agnes ;

Coindre, Jean-Michel ;

Italiano, Antoine ;

Orbach, Daniel ;

Debiec-Rychter, Maria ;

Chibon, Frederic .

JOURNAL OF CLINICAL ONCOLOGY, 2013, 31 (05) :608-615

[24] Mitotic Checkpoints and Chromosome Instability Are Strong Predictors of Clinical Outcome in Gastrointestinal Stromal Tumors [J].

Lagarde, Pauline ;

Perot, Gaelle ;

Kauffmann, Audrey ;

Brulard, Celine ;

Dapremont, Valerie ;

Hostein, Isabelle ;

Neuville, Agnes ;

Wozniak, Agnieszka ;

Sciot, Raf ;

Schoffski, Patrick ;

Aurias, Alain ;

Coindre, Jean-Michel ;

Debiec-Rychter, Maria ;

Chibon, Frederic .

CLINICAL CANCER RESEARCH, 2012, 18 (03) :826-838

[25] Comprehensive and Integrated Genomic Characterization of Adult Soft Tissue Sarcomas [J].

Lazar, Alexander J. ;

McLellan, Michael D. ;

Bailey, Matthew H. ;

Miller, Christopher A. ;

Appelbaum, Elizabeth L. ;

Cordes, Matthew G. ;

Fronick, Catrina C. ;

Fulton, Lucinda A. ;

Fulton, Robert S. ;

Mardis, Elaine R. ;

Schmidt, Heather K. ;

Wong, Winghing ;

Wilson, Richard K. ;

Yellapantula, Venkata ;

Radenbaugh, Amie J. ;

Hoadley, Katherine A. ;

Hayes, D. Neil ;

Parker, Joel S. ;

Wilkerson, Matthew D. ;

Auman, J. Todd ;

Balu, Saianand ;

Bodenheimer, Tom ;

Hoyle, Alan P. ;

Jefferys, Stuart R. ;

Jones, Corbin D. ;

Lehmann, Kjong-Van ;

Meng, Shaowu ;

Mieczkowski, Piotr A. ;

Mose, Lisle E. ;

Perou, Charles M. ;

Roach, Jeffrey ;

Senbabaoglu, Yasin ;

Shi, Yan ;

Simons, Janae V. ;

Skelly, Tara ;

Soloway, Matthew G. ;

Tan, Donghui ;

Veluvolu, Umadevi ;

Davis, Ian J. ;

Hepperla, Austin J. ;

Brohl, Andrew S. ;

Kasaian, Katayoon ;

Mungall, Karen ;

Sadeghi, Sara ;

Barthel, Floris P. ;

Verhaak, Roel ;

Hu, Xin ;

Chibon, Frederic ;

Cherniack, Andrew D. ;

Shih, Juliann .

CELL, 2017, 171 (04) :950-+

[26] Validation of the Complexity INdex in SARComas prognostic signature on formalin-fixed, paraffin-embedded, soft-tissue sarcomas [J].

Le Guellec, S. ;

Lesluyes, T. ;

Sarot, E. ;

Valle, C. ;

Filleron, T. ;

Rochaix, P. ;

Valentin, T. ;

Perot, G. ;

Coindre, J. -M. ;

Chibon, F. .

ANNALS OF ONCOLOGY, 2018, 29 (08) :1828-1835

[27] The CINSARC signature as a prognostic marker for clinical outcome in multiple neoplasms [J].

Lesluyes, Tom ;

Delespaul, Lucile ;

Coindre, Jean-Michel ;

Chibon, Frederic .

SCIENTIFIC REPORTS, 2017, 7

[28] RNA sequencing validation of the Complexity INdex in SARComas prognostic signature [J].

Lesluyes, Tom ;

Perot, Gaelle ;

Largeau, Marine Roxane ;

Brulard, Celine ;

Lagarde, Pauline ;

Dapremont, Valerie ;

Lucchesi, Carlo ;

Neuville, Agnes ;

Terrier, Philippe ;

Vince-Ranchere, Dominique ;

Mendez-Lago, Maria ;

Gut, Marta ;

Gut, Ivo ;

Coindre, Jean-Michel ;

Chibon, Frederic .

EUROPEAN JOURNAL OF CANCER, 2016, 57 :104-111

[29] Molecular signatures database (MSigDB) 3.0 [J].

Liberzon, Arthur ;

Subramanian, Aravind ;

Pinchback, Reid ;

Thorvaldsdottir, Helga ;

Tamayo, Pablo ;

Mesirov, Jill P. .

BIOINFORMATICS, 2011, 27 (12) :1739-1740

[30] The Nuclear Protein UHRF2 Is a Direct Target of the Transcription Factor E2F1 in the Induction of Apoptosis [J].

Lu, Huarui ;

Hallstrom, Timothy C. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2013, 288 (33) :23833-23843

← 1 2 3 4 5 →