CINSARC signature as a prognostic marker for clinical outcome in sarcomas and beyond

被引：31

作者：

Chibon, Frederic ^{[1
,2
]}

Lesluyes, Tom ^{[1
,3
,4
]}

Valentin, Thibaud ^{[1
,5
]}

Le Guellec, Sophie ^{[1
,2
]}

机构：

[1] INSERM, U1037, CRCT, Toulouse, France

[2] Inst Claudius Regaud, Dept Pathol, Toulouse, France

[3] Univ Bordeaux, Bordeaux, France

[4] Inst Claudius Regaud, Toulouse, France

[5] Inst Claudius Regaud, Dept Med Oncol, Toulouse, France

来源：

GENES CHROMOSOMES & CANCER | 2019年 / 58卷 / 02期

关键词：

chromosome instability; CINSARC; prognosis; sarcoma; SOFT-TISSUE SARCOMAS; GENE-EXPRESSION; CHROMOSOMAL INSTABILITY; TARGET; ANEUPLOIDY; KINASE; IDENTIFICATION; SPECIFICITY; INTEGRATION; DEFINITION;

D O I：

10.1002/gcc.22703

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Prognostication is a key issue for sarcoma patients' care as it triggers the therapeutic approach including chemotherapy, which is still not standard for localized patients. Current prognostic evaluation, based on the FNCLCC grading system, has recently been improved by the CINSARC signature outperforming histology-based grading system by identifying high-risk patients in every grade, even in those considered as low. CINSARC is an expression-based signature related to mitosis and chromosome integrity with prognostic value in a wide range of cancers additional to sarcoma. First developed with frozen material, CINSARC is now coupled with NanoString technology allowing evaluation from FFPE blocks used in clinical practice. Consequently, CINSARC is currently evaluated in clinical trials with a dual objective of demonstrating the benefit of chemotherapy in sarcoma patients and testing its response prediction. Considering its overarching value in oncology, its development is welcome in any cancers where the prognostication needs to be improved.

引用

页码：124 / 129

页数：6

共 50 条

[1] Transcription-mediated gene fusion in the human genome [J].

Akiva, P ;

Toporik, A ;

Edelheit, S ;

Peretz, Y ;

Diber, A ;

Shemesh, R ;

Novik, A ;

Sorek, R .

GENOME RESEARCH, 2006, 16 (01) :30-36

[2]

[Anonymous], 2012, WHO CLASSIFICATION T

[3]

[Anonymous], PLOS ONE

[4] Analysis of the prostate cancer cell line LNCaP transcriptome using a sequencing-by-synthesis approach [J].

Bainbridge, Matthew N. ;

Warren, Rene L. ;

Hirst, Martin ;

Romanuik, Tammy ;

Zeng, Thomas ;

Go, Anne ;

Delaney, Allen ;

Griffith, Malachi ;

Hickenbotham, Matthew ;

Magrini, Vincent ;

Mardis, Elaine R. ;

Sadar, Marianne D. ;

Siddiqui, Asim S. ;

Marra, Marco A. ;

Jones, Steven J. M. .

BMC GENOMICS, 2006, 7 (1)

[5] The Multifaceted Role of Chromosomal Instability in Cancer and Its Microenvironment [J].

Bakhoum, Samuel F. ;

Cantley, Lewis C. .

CELL, 2018, 174 (06) :1347-1360

[6] Chromosomal instability drives metastasis through a cytosolic DNA response [J].

Bakhoum, Samuel F. ;

Ngo, Bryan ;

Laughney, Ashley M. ;

Cavallo, Julie-Ann ;

Murphy, Charles J. ;

Ly, Peter ;

Shah, Pragya ;

Sriram, Roshan K. ;

Watkins, Thomas B. K. ;

Taunk, Neil K. ;

Duran, Mercedes ;

Pauli, Chantal ;

Shaw, Christine ;

Chadalavada, Kalyani ;

Rajasekhar, Vinagolu K. ;

Genovese, Giulio ;

Venkatesan, Subramanian ;

Birkbak, Nicolai J. ;

McGranahan, Nicholas ;

Lundquist, Mark ;

LaPlant, Quincey ;

Healey, John H. ;

Elemento, Olivier ;

Chung, Christine H. ;

Lee, Nancy Y. ;

Imielenski, Marcin ;

Nanjangud, Gouri ;

Pe'er, Dana ;

Cleveland, Don W. ;

Powell, Simon N. ;

Lammerding, Jan ;

Swanton, Charles ;

Cantley, Lewis C. .

NATURE, 2018, 553 (7689) :467-+

[7] Soft tissue and visceral sarcomas: ESMO-EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up (vol 29, pg 51, 2018) [J].

Casali, P. G. ;

Abecassis, N. ;

Aro, H. T. ;

Bauer, S. ;

Biagini, R. ;

Bielack, S. ;

Bonvalot, S. ;

Boukovinas, I. ;

Bovee, J. V. M. G. ;

Brodovvicz, T. ;

Broto, J. M. ;

Buonadonna, A. ;

De Alava, E. ;

Tos, A. P. Dei ;

Del Muro, X. G. ;

Dileo, P. ;

Eriksson, M. ;

Fedenko, A. ;

Ferraresi, V. ;

Ferrari, A. ;

Ferrari, S. ;

Frezza, A. M. ;

Gasperoni, S. ;

Gelderblom, H. ;

Gil, T. ;

Grignani, G. ;

Gronchi, A. ;

Haas, R. L. ;

Hassan, B. ;

Hohenberger, P. ;

Lssels, R. ;

Joensuu, H. ;

Jones, R. L. ;

Judson, I. ;

Jutte, P. ;

Kaal, S. ;

Kasper, B. ;

Kopeckova, K. ;

Krakorova, D. A. ;

Le Cesne, A. ;

Lugowska, I. ;

Merimsky, O. ;

Montemurro, M. ;

Pantaleo, M. A. ;

Piana, R. ;

Picci, P. ;

Piperno-Neumann, S. ;

Pousa, A. L. ;

Reichardt, P. ;

Robinson, M. H. .

ANNALS OF ONCOLOGY, 2018, 29 :268-269

[8] Detection of single nucleotide variations in expressed exons of the human genome using RNA-Seq [J].

Chepelev, Iouri ;

Wei, Gang ;

Tang, Qingsong ;

Zhao, Keji .

NUCLEIC ACIDS RESEARCH, 2009, 37 (16) :e106-e106

[9]

Chibon F, 2000, CANCER RES, V60, P6339

[10] Validated prediction of clinical outcome in sarcomas and multiple types of cancer on the basis of a gene expression signature related to genome complexity [J].

Chibon, Frederic ;

Lagarde, Pauline ;

Salas, Sebastien ;

Perot, Gaelle ;

Brouste, Veronique ;

Tirode, Franck ;

Lucchesi, Carlo ;

de Reynies, Aurelien ;

Kauffmann, Audrey ;

Bui, Binh ;

Terrier, Philippe ;

Bonvalot, Sylvie ;

Le Cesne, Axel ;

Vince-Ranchere, Dominique ;

Blay, Jean-Yves ;

Collin, Francoise ;

Guillou, Louis ;

Leroux, Agnes ;

Coindre, Jean-Michel ;

Aurias, Alain .

NATURE MEDICINE, 2010, 16 (07) :781-U81

← 1 2 3 4 5 →