Spiroplakortone, an unprecedented spiroketal lactone from the Chinese sponge Plakortis simplex

被引：10

作者：

Chianese, Giuseppina ^{[1
]}

Gu, Bin-Bin ^{[2
]}

Yang, Fan ^{[2
]}

Jiao, Wei-Hua ^{[2
]}

Guo, Yue-Wei ^{[3
]}

Lin, Hou-Wen ^{[2
]}

Taglialatela-Scafati, Orazio ^{[1
]}

机构：

[1] Univ Naples Federico II, Dipartimento, Farm, I-80131 Naples, Italy

[2] Renji Hosp, Sch Med, State Key Lab Oncogenes & Related Genes, Key Lab Marine Drugs,Dept Pharm, Shanghai 200127, Peoples R China

[3] Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China

来源：

RSC ADVANCES | 2015年 / 5卷 / 78期

关键词：

NATURAL-PRODUCTS; POLYKETIDES; STEREOCHEMISTRY; METABOLITES;

D O I：

10.1039/c5ra09840h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new polyketide-based metabolite, spiroplakortone (1), characterized as an unprecedented gamma-spiroketalg-lactone, was obtained from the Chinese sponge Plakortis simplex. Structural characterization of spiroplakortone (1) was based on extensive spectroscopic analysis and its configuration was partly established by GIAO C-13-NMR, supported by DP4 probability analysis, and ECD calculations. A plausible pathway for the biosynthesis of spiroplakortone (1), envisaging the formation of a carbon-carbon linkage between polyketide and aminoacid (leucine)-derived moieties, has been proposed.

引用

页码：63372 / 63376

页数：5

共 26 条

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[4]

2-0