Association between maternal circulating 25 hydroxyvitamin D concentration and placental volume in the first trimester

Objectives: We aimed to assess placental volume and placental mean gray value in vitamin D deficiency and healthy placentas in the first trimester of pregnancy using three-dimensional (3D) ultrasonography (USG) and Virtual Organ Computer-aided Analysis (VOCAL). Methods: This prospective cross sectional study comprised 274 patients, divided into two groups according to the presence or absence of vitamin D deficiency (<20ng/ml deficient, n=153, >20ng/ml not deficient, n=121) in the first trimester of pregnancy. Placental volume and placental volumetric mean gray values were evaluated. Placental volume (cm(3)) was analyzed using the VOCAL imaging program and a 3D histogram was used to calculate the volumetric mean gray value (%). Results: Placental volume was significantly less in the vitamin D deficiency group (p=0.017) Volumetric mean gray value of the placenta was significantly higher in the vitamin D deficiency group (p=0.003). Maternal serum PAPP-A (MoM) and f- Hcg (MoM) were significantly lower in the vitamin D deficiency group (p=0.008, p=0.003, respectively). In linear regression analyses, serum vitamin D concentration was significantly associated with the plasental volume (=0.16; p=0.01). Conclusion: Placental configuration and development were associated with vitamin D even in the first trimester of pregnancy. To ensure healthy pregnancy outcomes, vitamin D screening applied in the early stages of pregnancy or even before pregnancy.