Antibacterial pyrazoles: tackling resistant bacteria

被引：44
作者：
Alam, Mohammad A. [1 ]
机构：
[1] Arkansas State Univ, Dept Chem & Phys, Coll Sci & Math, Jonesboro, AR 72401 USA
来源：
FUTURE MEDICINAL CHEMISTRY | 2022年 / 14卷 / 05期
基金：
美国国家卫生研究院;
关键词：
Acinetobacter baumannii; antibacterial; antibiotics; antimicrobials; bacterial resistance; drug-resistant; ESKAPE pathogens; MRSA; pyrazole; EXTENSIVELY DRUG-RESISTANT; POTENT GROWTH-INHIBITORS; BIOLOGICAL EVALUATION; MOLECULAR DOCKING; ANTIBIOTIC-RESISTANCE; DNA GYRASE; DERIVATIVES; DESIGN; DISCOVERY; ACID;
D O I：
10.4155/fmc-2021-0275
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Bacterial resistance to antibiotics threatens our progress in healthcare, modern medicine, food production and ultimately life expectancy. Antibiotic resistance is a global concern, which spreads rapidly across borders and continents due to rapid travel of people, animals and goods. Derivatives of metabolically stable pyrazole nucleus are known for their wide range of pharmacological properties, including antibacterial activities. This review highlights recent reports of pyrazole derivatives targeting different bacterial strains focusing on the drug-resistant variants. Pyrazole derivatives target different metabolic pathways of both Gram-positive and Gram-negative bacteria.
引用
收藏
页码：343 / 362
页数：20
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