The role of Ki-67 in breast cancer

被引:3
作者
Mannell, A. [1 ]
机构
[1] Univ Witwatersrand, Dept Surg, Johannesburg, South Africa
关键词
NEOADJUVANT CHEMOTHERAPY; ENDOCRINE THERAPY; RANDOMIZED-TRIAL; KI67; TAMOXIFEN; RECURRENCE; RECOMMENDATIONS; ANASTROZOLE; EXPRESSION; PROGNOSIS;
D O I
暂无
中图分类号
R61 [外科手术学];
学科分类号
摘要
The proliferative marker, Ki-67, is a human nuclear antigen, and forms an integral part of cell division in both normal and malignant tissue. Since the hallmark of cancer is uncontrolled and relentless cell proliferation, the Ki-67 proliferative index is increasingly used to assess and manage breast cancer. The value of Ki-67 as a prognostic indicator, a guide to the selection of therapy, and a method of measuring response to ongoing treatment, is examined in this review.
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页码:10 / 13
页数:4
相关论文
共 26 条
[1]  
Agboola AO, 2013, ISRN ONCOL
[2]  
Billgren AM, 1999, ACTA ONCOL, V38, P597
[3]   Ki67 Index, HER2 Status, and Prognosis of Patients With Luminal B Breast Cancer [J].
Cheang, Maggie C. U. ;
Chia, Stephen K. ;
Voduc, David ;
Gao, Dongxia ;
Leung, Samuel ;
Snider, Jacqueline ;
Watson, Mark ;
Davies, Sherri ;
Bernard, Philip S. ;
Parker, Joel S. ;
Perou, Charles M. ;
Ellis, Matthew J. ;
Nielsen, Torsten O. .
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2009, 101 (10) :736-750
[4]   Tailoring therapies-improving the management of early breast cancer: St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2015 [J].
Coates, A. S. ;
Winer, E. P. ;
Goldhirsch, A. ;
Gelber, R. D. ;
Gnant, M. ;
Piccart-Gebhart, M. ;
Thuerlimann, B. ;
Senn, H. -J. .
ANNALS OF ONCOLOGY, 2015, 26 (08) :1533-1546
[5]   Prognostic Value of a Combined Estrogen Receptor, Progesterone Receptor, Ki-67, and Human Epidermal Growth Factor Receptor 2 Immunohistochemical Score and Comparison With the Genomic Health Recurrence Score in Early Breast Cancer [J].
Cuzick, Jack ;
Dowsett, Mitch ;
Pineda, Silvia ;
Wale, Christopher ;
Salter, Janine ;
Quinn, Emma ;
Zabaglo, Lila ;
Mallon, Elizabeth ;
Green, Andrew R. ;
Ellis, Ian O. ;
Howell, Anthony ;
Buzdar, Aman U. ;
Forbes, John F. .
JOURNAL OF CLINICAL ONCOLOGY, 2011, 29 (32) :4273-4278
[6]   Effect of anastrozole and tamoxifen as adjuvant treatment for early-stage breast cancer: 10-year analysis of the ATAC trial [J].
Cuzick, Jack ;
Sestak, Ivana ;
Baum, Michael ;
Buzdar, Aman ;
Howell, Anthony ;
Dowsett, Mitch ;
Forbes, John F. .
LANCET ONCOLOGY, 2010, 11 (12) :1135-1141
[7]   Long-term effects of continuing adjuvant tamoxifen to 10 years versus stopping at 5 years after diagnosis of oestrogen receptor-positive breast cancer: ATLAS, a randomised trial [J].
Davies, Christina ;
Pan, Hongchao ;
Godwin, Jon ;
Gray, Richard ;
Arriagada, Rodrigo ;
Raina, Vinod ;
Abraham, Mirta ;
Medeiros Alencar, Victor Hugo ;
Badran, Atef ;
Bonfill, Xavier ;
Bradbury, Joan ;
Clarke, Michael ;
Collins, Rory ;
Davis, Susan R. ;
Delmestri, Antonella ;
Forbes, John F. ;
Haddad, Peiman ;
Hou, Ming-Feng ;
Inbar, Moshe ;
Khaled, Hussein ;
Kielanowska, Joanna ;
Kwan, Wing-Hong ;
Mathew, Beela S. ;
Mittra, Indraneel ;
Mueller, Bettina ;
Nicolucci, Antonio ;
Peralta, Octavio ;
Pernas, Fany ;
Petruzelka, Lubos ;
Pienkowski, Tadeusz ;
Radhika, Ramachandran ;
Rajan, Balakrishnan ;
Rubach, Maryna T. ;
Tort, Sera ;
Urrutia, Gerard ;
Valentini, Miriam ;
Wang, Yaochen ;
Peto, Richard .
LANCET, 2013, 381 (9869) :805-816
[8]   Ki-67 as prognostic marker in early breast cancer: a meta-analysis of published studies involving 12 155 patients [J].
de Azambuja, E. ;
Cardoso, F. ;
de Castro, G., Jr. ;
Colozza, M. ;
Mano, M. S. ;
Durbecq, V. ;
Sotiriou, C. ;
Larsimont, D. ;
Piccart-Gebhart, M. J. ;
Paesmans, M. .
BRITISH JOURNAL OF CANCER, 2007, 96 (10) :1504-1513
[9]   Prognostic value of Ki67 expression after short-term presurgical endocrine therapy for primary breast cancer [J].
Dowsett, Mitch ;
Smith, Ian E. ;
Ebbs, Stephen R. ;
Dixon, J. Michael ;
Skene, Anthony ;
A'Hern, Roger ;
Salter, Janine ;
Detre, Simone ;
Hills, Margaret ;
Walsh, Geraldine .
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2007, 99 (02) :167-170
[10]  
Dowsett Mitch, 2011, Journal of the National Cancer Institute Monographs, P120, DOI 10.1093/jncimonographs/lgr034