Effect of preinterventional arterial remodeling on intimal hyperplasia after implantation of a polymer-based paclitaxel-eluting stent: Angiographic and IVUS study

被引：5

作者：

Kang, Woong Chol ^{[1
]}

Oh, Kyu Jin ^{[1
]}

Han, Seung Hwan ^{[1
]}

Ahn, Tae Hoon ^{[1
]}

Chung, Wook-Jin ^{[1
]}

Shin, Mi-Seung ^{[1
]}

Koh, Kwang Kon ^{[1
]}

Choi, In Suck ^{[1
]}

Shin, Eak Kyun ^{[1
]}

机构：

[1] Gachon Univ Med & Sci, Gil Med Ctr, Div Cardiol, Inchon 405760, South Korea

来源：

INTERNATIONAL JOURNAL OF CARDIOLOGY | 2007年 / 123卷 / 01期

关键词：

arterial remodeling; remodeling index; polymer-based paclitaxel-eluting stent; intimal hyperplasia;

D O I：

10.1016/j.ijcard.2006.11.131

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: The aim of this study was to evaluate the effect of preinterventional arterial remodeling on in-stent intimal hyperplasia (IH) after the implantation of a polymer-based paclitaxel-eluting stent. Methods: The study population consisted of 55 patients (61 lesions) with a de novo lesion treated with a paclitaxel-eluting stent. The lesions were divided into two groups, positive or intermediate (PR/IR), and negative remodeling (NR) groups, according to the preinterventional arterial remodeling. Angiographic and IVUS examinations were performed preintervention, postintervention and at 9 months of follow-up. Results: The remodeling index (RI) was 1.19 +/- 0.16 in the PR/IR group and 0.81 +/- 0.10 in the NR group. At follow-up, the late loss was significantly larger in the PR/IR group than in the IR group. (0.65 +/- 0.58 mm vs. 0.29 +/- 0.5 mm, p= 0.017). The external elastic membrane cross-sectional area (CSA) (18.68 +/- 5.39 vs. 12.87 +/- 3.72 mm(2), p= 0.000), plaque CSA (16.99 +/- 4.04 vs. 10.34 +/- 3.45 Mm(2), p= 0.000) and plaque index (85.84 +/- 5.02 vs. 81.80 +/- 7.26%, p= 0.048) during the preintervention period and IH volume during the follow-up were significantly larger in the PR/IR group than in the NR group (17.98 +/- 16.7 mm3 vs. 4.59 +/- 12.4 mm(3); p<0.001). Further, the percentage of the change in the IH was also larger in the PR/ IR group than in the NR group (13.49 +/- 11.78% vs. 4.12 +/- 10.76%; p= 0.002). A significant positive correlation was found between the preinterventional RI and follow-up IH CSA (r=0.406, p=0.001). Conclusions: The preinterventional arterial remodeling influenced the development of the IH after the implantation of the polymer-based paclitaxel-eluting stent which had a greater effect on reducing the IH accumulation in the lesions with preinterventional negative remodeling characteristics. (C) 2007 Elsevier Ireland Ltd. All rights reserved.

引用

页码：50 / 54

页数：5

共 20 条

[1] Relationship between residual atheroma burden and neointimal growth in patients undergoing stenting - Analysis of the atherectomy before MULTI-LlNK improves lumen gain and clinical outcomes trial intravascular ultrasound substudy [J].