Vitamin D improves endothelial function in patients with Type 2 diabetes mellitus and low vitamin D levels

被引:483
作者
Sugden, J. A. [1 ,2 ]
Davies, J. I.
Witham, M. D. [1 ,2 ]
Morris, A. D.
Struthers, A. D.
机构
[1] Univ Dundee, Div Med & Therapeut, Sect Ageing & Hlth, Dundee DD1 9SY, Scotland
[2] Ninewells Hosp, Sch Med, Dundee DD1 9SY, Scotland
关键词
blood pressure; endothelial function; vitamin D;
D O I
10.1111/j.1464-5491.2007.02360.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Aims To test whether a single large dose of vitamin D2 can improve endothelial function in patients with Type 2 diabetes mellitus and low serum 25-hydroxyvitamin D levels. Methods Double-blind, parallel group, placebo-controlled randomized trial. A single dose of 100 000 IU vitamin D2 or placebo was administered to patients with Type 2 diabetes over the winter, when levels of circulating 25-hydroxyvitamin D were likely to be lowest. Patients were enrolled if their baseline 25-hydroxyvitamin D level was < 50 nmol/l. Endothelial function and blood pressure were measured and fasting blood samples were taken at baseline and 8 weeks after administration of vitamin D. Results Forty-nine per cent of subjects screened had 25-hydroxyvitamin D levels < 50 nmol/l. Thirty-four subjects completed the study, with a mean age of 64 years and a baseline 25-hydroxyvitamin D level of 38.3 nmol/l. Vitamin D supplementation increased 25-hydroxyvitamin D levels by 15.3 nmol/l relative to placebo and significantly improved flow mediated vasodilatation (FMD) of the brachial artery by 2.3%. The improvement in FMD remained significant after adjusting for changes in blood pressure. Vitamin D supplementation significantly decreased systolic blood pressure by 14 mmHg compared with placebo; this did not correlate with change in FMD. Conclusions Vitamin D insufficiency is common in patients with Type 2 diabetes during winter in Scotland. A single large dose of oral vitamin D2 improves endothelial function in patients with Type 2 diabetes and vitamin D insufficiency.
引用
收藏
页码:320 / 325
页数:6
相关论文
共 50 条
[41]   Relationship between vitamin D and glycemic control in patients with type 2 diabetes mellitus [J].
Olt, Serdar .
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2015, 8 (10) :19180-19183
[42]   The effect of vitamin D deficiency on glycemic control in patients with type 2 diabetes mellitus [J].
Mostafa, Neveen Rashad ;
Ali, Abeer Ahmed Mohamed ;
Marzo, Roy Rillera .
HEALTHCARE IN LOW-RESOURCE SETTINGS, 2023, 11
[43]   Diabetic regulation of subjects with type 2 diabetes mellitus is associated with serum vitamin D levels [J].
Erkus, Edip ;
Aktas, Gulali ;
Kocak, M. Zahid ;
Duman, Tuba T. ;
Atak, Burcin M. ;
Savli, Haluk .
REVISTA DA ASSOCIACAO MEDICA BRASILEIRA, 2019, 65 (01) :51-55
[44]   Association of Vitamin D Levels and type 2 Diabetes Mellitus in Asian Indians is Independent of Obesity [J].
Gupta, A. ;
Aslam, M. ;
Rathi, S. ;
Mishra, B. K. ;
Bhardwaj, S. ;
Jhamb, R. ;
Madhu, S. V. .
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES, 2018, 126 (09) :553-558
[45]   Low serum vitamin D levels in type 2 diabetes patients are associated with decreased mycobacterial activity [J].
María Teresa Herrera ;
Yolanda Gonzalez ;
Fernando Hernández-Sánchez ;
Guadalupe Fabián-San Miguel ;
Martha Torres .
BMC Infectious Diseases, 17
[46]   Low serum vitamin D levels in type 2 diabetes patients are associated with decreased mycobacterial activity [J].
Teresa Herrera, Maria ;
Gonzalez, Yolanda ;
Hernandez-Sanchez, Fernando ;
Fabian-San Miguel, Guadalupe ;
Torres, Martha .
BMC INFECTIOUS DISEASES, 2017, 17
[47]   Vitamin D and Type 1 Diabetes Mellitus in Children [J].
Tjahjono, Harjoedi Adji .
HORMONE RESEARCH IN PAEDIATRICS, 2019, 91 :645-646
[48]   Vitamin D and type 2 diabetes [J].
Eliades M. ;
Pittas A.G. .
Clinical Reviews in Bone and Mineral Metabolism, 2009, 7 (2) :185-198
[49]   Can Vitamin D be a potential treatment for Type 2 diabetes mellitus [J].
Meerza, D. ;
Naseem, I. ;
Ahmed, J. .
DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS, 2010, 4 (04) :245-248
[50]   Effect of Vitamin D Supplementation on Pancreatic B -Cell Function in Patients with Type 1 Diabetes Mellitus and Vitamin D Deficiency: A Clinical Trial Study [J].
Aghamaleki, Morteza Alijanpour ;
Hajiahmadi, Mahmoud ;
Pornasrollah, Mohammad ;
Oruji, Zahra ;
Aghajanpour, Faeze .
INTERNATIONAL JOURNAL OF PEDIATRICS-MASHHAD, 2019, 7 (02) :8977-8984