Vitamin D improves endothelial function in patients with Type 2 diabetes mellitus and low vitamin D levels

被引:483
作者
Sugden, J. A. [1 ,2 ]
Davies, J. I.
Witham, M. D. [1 ,2 ]
Morris, A. D.
Struthers, A. D.
机构
[1] Univ Dundee, Div Med & Therapeut, Sect Ageing & Hlth, Dundee DD1 9SY, Scotland
[2] Ninewells Hosp, Sch Med, Dundee DD1 9SY, Scotland
关键词
blood pressure; endothelial function; vitamin D;
D O I
10.1111/j.1464-5491.2007.02360.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Aims To test whether a single large dose of vitamin D2 can improve endothelial function in patients with Type 2 diabetes mellitus and low serum 25-hydroxyvitamin D levels. Methods Double-blind, parallel group, placebo-controlled randomized trial. A single dose of 100 000 IU vitamin D2 or placebo was administered to patients with Type 2 diabetes over the winter, when levels of circulating 25-hydroxyvitamin D were likely to be lowest. Patients were enrolled if their baseline 25-hydroxyvitamin D level was < 50 nmol/l. Endothelial function and blood pressure were measured and fasting blood samples were taken at baseline and 8 weeks after administration of vitamin D. Results Forty-nine per cent of subjects screened had 25-hydroxyvitamin D levels < 50 nmol/l. Thirty-four subjects completed the study, with a mean age of 64 years and a baseline 25-hydroxyvitamin D level of 38.3 nmol/l. Vitamin D supplementation increased 25-hydroxyvitamin D levels by 15.3 nmol/l relative to placebo and significantly improved flow mediated vasodilatation (FMD) of the brachial artery by 2.3%. The improvement in FMD remained significant after adjusting for changes in blood pressure. Vitamin D supplementation significantly decreased systolic blood pressure by 14 mmHg compared with placebo; this did not correlate with change in FMD. Conclusions Vitamin D insufficiency is common in patients with Type 2 diabetes during winter in Scotland. A single large dose of oral vitamin D2 improves endothelial function in patients with Type 2 diabetes and vitamin D insufficiency.
引用
收藏
页码:320 / 325
页数:6
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