Intravesical heparin and peripheral neuromodulation on interstitial cystitis

被引:14
作者
Baykal, K [1 ]
Senkul, T [1 ]
Sen, B [1 ]
Karademir, K [1 ]
Adayener, C [1 ]
Erden, D [1 ]
机构
[1] GATA Haydarpasa Training Hosp, Dept Urol, TR-34668 Uskudar, Istanbul, Turkey
关键词
heparin; neuromodulation; interstitial cystitis;
D O I
10.1159/000084439
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Introduction: We wanted to evaluate the therapeutic effect of intravesical heparin and peripheral neuromodulation on patients with interstitial cystitis. Materials and Methods: From March 2002 to August 2003, 8 female and 2 male subjects conform to the NIDDK criteria and not responsive to the previous conventional treatments were included in the study. Wisconsin pain scores, maximal cystometric capacities, and night and day voiding frequencies were determined and these studies were repeated in the 2nd and 12th months of the treatment with 10,000 units intravesical heparin and peripheral neuromodulation. Frequency of the treatment was once a week during first 8 weeks, once in 2 weeks in the following 8 weeks, and once in 3 weeks four times. Then, it was decreased to once a month. Results: The mean follow-up period was 13 months (12-16 months). Day and night voiding frequency were significantly better in the 2nd and 12th months, when compared to pretreatment values. The Wisconsin pain scores were 62.5 +/- 13.9% and 62.8 +/- 15.2% in the 2nd and the 12th months, respectively. The average increase in the maximum cystometric capacity was 54.8 +/- 27.4% and 52.5 +/- 31.6% in the 2nd and the 12th months, respectively. Conclusions: Intravesical heparin and peripheral neuromodulation combination seems to be an alternative for patients with interstitial cystitis not responsive to other treatments. Copyright (c) 2005 S. Karger AG, Basel.
引用
收藏
页码:361 / 364
页数:4
相关论文
共 26 条
[1]   Sacral neuromodulation for the symptomatic treatment of refractory interstitial cystitis: A prospective study [J].
Comiter, CV .
JOURNAL OF UROLOGY, 2003, 169 (04) :1369-1373
[2]   Nitric oxide:: A useful gas in the detection of lower urinary tract inflammation [J].
Ehrén, I ;
Hosseini, A ;
Lundberg, JON ;
Wiklund, NP .
JOURNAL OF UROLOGY, 1999, 162 (02) :327-329
[3]  
ELBADAWI A, 2003, UROLOGY S, V49, P14
[4]   A CLINICOPATHOLOGICAL AND VIROLOGICAL STUDY OF INTERSTITIAL CYSTITIS [J].
FALL, M ;
JOHANSSON, SL ;
VAHLNE, A .
JOURNAL OF UROLOGY, 1985, 133 (05) :771-773
[5]  
Galloway N T, 1991, Semin Urol, V9, P148
[6]   Percutaneous afferent neuromodulation for the refractory overactive bladder: Results of a multicenter study [J].
Govier, FE ;
Litwiller, S ;
Nitti, V ;
Kreder, KJ ;
Rosenblatt, P .
JOURNAL OF UROLOGY, 2001, 165 (04) :1193-1198
[7]   INTERSTITIAL CYSTITIS - REPORT OF 223 CASES (204 WOMEN AND 19 MEN) [J].
HAND, JR .
JOURNAL OF UROLOGY, 1949, 61 (02) :291-310
[8]   Analysis of long-term Elmiron therapy for interstitial cystitis [J].
Hanno, PM .
UROLOGY, 1997, 49 (5A) :93-99
[9]   INTERSTITIAL CYSTITIS - BLADDER MUCOSA LYMPHOCYTE IMMUNOPHENOTYPING AND PERIPHERAL-BLOOD FLOW-CYTOMETRY ANALYSIS [J].
HARRINGTON, DS ;
FALL, M ;
JOHANSSON, SL .
JOURNAL OF UROLOGY, 1990, 144 (04) :868-871
[10]   Use of peripheral neuromodulation of the S3 region for treatment of detrusor overactivity: A urodynamic-based study [J].
Klingler, HC ;
Pycha, A ;
Schmidbauer, J ;
Marberger, M .
UROLOGY, 2000, 56 (05) :766-771