Role of protein phosphatase 2A in kidney disease (Review)

被引：9
作者：
Shao, Lishi [1 ,2 ]
Ma, Yiqun [1 ,2 ]
Fang, Qixiang [3 ]
Huang, Ziye [2 ,4 ]
Wan, Shanshan [5 ]
Wang, Jiaping [1 ,2 ]
Yang, Li [6 ]
机构：
[1] Kunming Med Univ, Dept Radiol, 374 Dianmian Ave, Kunming 650500, Yunnan, Peoples R China
[2] Second Affiliated Hosp, 374 Dianmian Ave, Kunming 650500, Yunnan, Peoples R China
[3] Xi An Jiao Tong Univ, Dept Urol, Affiliated Hosp 1, Med Coll, Xian 710049, Shaanxi, Peoples R China
[4] Kunming Med Univ, Dept Urol, Kunming 650500, Yunnan, Peoples R China
[5] Yunnan Kun Gang Hosp, Dept Radiol, 2 Ganghe South Rd, Anning 650300, Yunnan, Peoples R China
[6] Kunming Med Univ, Dept Anat Histol & Embryol, Kunming 650500, Yunnan, Peoples R China
来源：
EXPERIMENTAL AND THERAPEUTIC MEDICINE | 2021年 / 22卷 / 05期
基金：
中国国家自然科学基金;
关键词：
protein phosphatase 2A; kidney disease; ion channel; aquaporin-2; development; podocyte; carcinoma; chronic kidney disease; epithelial-mesenchymal transition; inflammation; NF-KAPPA-B; RENAL INTERSTITIAL FIBROSIS; OKADAIC ACID; NA+-ATPASE; MESENCHYMAL TRANSITION; TYROSINE-PHOSPHATASES; PP2A REGULATION; KINASE ACTIVITY; BLOOD-PRESSURE; PHOSPHORYLATION;
D O I：
10.3892/etm.2021.10671
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Kidney disease affects millions of people worldwide and is a financial burden on the healthcare system. Protein phosphatase 2A (PP2A), which is involved in renal development and the function of ion-transport proteins, aquaporin-2 and podocytes, is likely to serve an important role in renal processes. PP2A is associated with the pathogenesis of a variety of different kidney diseases including podocyte injury, inflammation, tumors and chronic kidney disease. The current review aimed to discuss the structure and function of PP2A subunits in the context of kidney diseases. How dysregulation of PP2A in the kidneys causes podocyte death and the inactivation of PP2A in renal carcinoma tissues is discussed. Inhibition of PP2A activity prevents epithelial-mesenchymal transition and attenuates renal fibrosis, creating a favorable inflammatory microenvironment and promoting the initiation and progression of tumor pathogenesis. The current review also indicates that PP2A serves an important role in protection against renal inflammation. Understanding the detailed mechanisms of PP2A provides information that can be utilized in the design and application of novel therapeutics for the treatment and prevention of renal diseases.
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页数：10
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