The Human Microbiota in Multiple Myeloma and Proteasome Inhibitors

被引：20

作者：

Alkharabsheh, Omar ^{[1
]}

Sidiqi, M. Hasib ^{[2
]}

Aljama, Mohammed A. ^{[3
]}

Gertz, Morie A. ^{[2
]}

Frankel, Arthur E. ^{[1
]}

机构：

[1] Univ S Alabama, Mitchell Canc Inst, Div Med Oncol, Mobile, AL USA

[2] Mayo Clin, Dept Med, Div Hematol, Rochester, MN USA

[3] McMaster Univ, Dept Oncol, Div Malignant Hematol, Hamilton, ON, Canada

来源：

ACTA HAEMATOLOGICA | 2020年 / 143卷 / 02期

关键词：

Multiple myeloma; Proteasome inhibitors; Microbiota; CHAIN FATTY-ACIDS; VERSUS-HOST-DISEASE; INTESTINAL MICROBIOTA; KAPPA-B; HOMEOSTASIS; BORTEZOMIB; EVENTS; CELLS;

D O I：

10.1159/000500976

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The gut microbiota plays a significant role in health and disease, including cancer development and treatment. The importance of the gut microbiota in the efficacy and toxicity of novel therapies and immunotherapy is increasingly recognized. Plasma cells in multiple myeloma have the potential to survive in the gastrointestinal tract for long periods of time. The nature of the gut microbiota impacts the degree of antigen stimulation of these cells and may play a role in mutation development and clonal evolution. Furthermore, myeloma therapies such as proteasome inhibitors and alkylating agents, commonly used to treat patients, are frequently associated with gastrointestinal adverse events. Herein we review the gut microbiota and its role in hematopoiesis, pathogenesis of myeloma, and efficacy/toxicity of anti-myeloma therapies.

引用

页码：118 / 123

页数：6

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