The first observation of osmotically neutral sodium accumulation in the myocardial interstitium

被引：4

作者：

Artyukov, I ^{[1
]}

Arutyunov, G. ^{[2
]}

Bobrov, M. ^{[3
]}

Bukreeva, I ^{[1
,4
]}

Cedola, A. ^{[4
]}

Dragunov, D. ^{[2
]}

Feshchenko, R. ^{[1
]}

Fratini, M. ^{[4
]}

Mitrokhin, V ^{[2
]}

Sokolova, A. ^{[2
]}

Vinogradov, A. ^{[1
]}

Gianoncelli, A. ^{[5
]}

机构：

[1] RAS, PN Lebedev Phys Inst, 53 Leninsky Prospekt, Moscow 119991, Russia

[2] Pirogov Russian Natl Res Med Univ, 1 Ostrovitianov St, Moscow 117997, Russia

[3] Moscow Reg Res & Clin Inst MONIKI, 61-2 Shchepkina St, Moscow 129110, Russia

[4] CNR Inst Nanotechnol, 5 Piazzale Aldo Moro, I-00185 Rome, Italy

[5] Elettra Sincrotrone Trieste, SS 14,Km 163-5 Area Sci Pk, I-34149 Basovizza Trieste, Italy

来源：

SCIENTIFIC REPORTS | 2021年 / 11卷 / 01期

关键词：

X-RAY TRANSMISSION; NA+ STORAGE; BALANCE; CELLS;

D O I：

10.1038/s41598-021-01443-8

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The aim of this study was the detection and quantification of the Na+ depositions in the extracellular matrix of myocardial tissue, which are suggested to be bound by negatively charged glycosaminoglycan (GAG) structures. The presented experimental results are based on high resolution X-ray fluorescence (XRF) spectromicroscopy technique used to perform a comparative analysis of sodium containment in intracellular and interstitial spaces of cardiac tissues taken from animals selected by low and high sodium intake rates. The experimental results obtained show that high sodium daily intake can result in a remarkable increase of sodium content in the myocardial interstitium.

引用

页数：8

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