Solvent inhalation (toluene and n-hexane) during the brain growth spurt impairs the maturation of frontal, parietal and occipital cerebrocortical neurons in rats

被引：7

作者：

Pascual, Rodrigo ^{[1
]}

Aedo, Luz ^{[1
]}

Carlos Meneses, Juan ^{[1
]}

Vergara, Daniela ^{[1
]}

Reyes, Alvaro ^{[1
]}

Bustamante, Carlos ^{[1
]}

机构：

[1] Pontificia Univ Catolica Valparaiso, Fac Ciencias, Escuela Kinesiol, Lab Neurociencias, Valparaiso, Chile

来源：

INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE | 2010年 / 28卷 / 06期

关键词：

Solvent inhalation; Dendritic development; Cortical neurons; Brain growth spurt; DEVELOPMENTAL NEUROTOXICITY; SUBUNIT EXPRESSION; VISUAL-CORTEX; EXPOSURE; BEHAVIOR; ABUSE; SENSITIVITY; RECEPTORS;

D O I：

10.1016/j.ijdevneu.2010.06.003

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Solvent abuse during pregnancy may cause "fetal solvent syndrome", which is characterized by mild brain atrophy and associated with behavioral, cognitive, and emotional abnormalities. The present study investigated whether solvent inhalation during the preweaning period (P2-P21) alters the morphological maturation of frontal, parietal, and occipital cortical neurons. Twelve hours after delivery (postnatal day 0, PO), litters were cross-fostered, culled to 8 pups/dam and housed together with a dam in standard laboratory cages. Litters were randomly assigned to the "air-only" group (n = 64, 8 litters) and to the "solvent-sniffer" group (n = 72, 9 litters). During P2-P21, each animal was exposed daily to either organic solvent vapors (75% toluene and 18% n-hexane, a solvent mixture commonly found in glues and adhesives) or clean air. To determine the impact of early solvent inhalation on cortical neuronal differentiation, brains were stained using the Golgi-Cox-Sholl procedure to quantitatively assess neocortical pyramidal cell dendrogenesis. Preweaning, solvent-exposed animals displayed dramatic impairments in dendritic growth as well as significant reductions in brain weight and size. (C) 2010 ISDN. Published by Elsevier Ltd. All rights reserved.

引用

页码：491 / 495

页数：5

共 38 条

[31] VOLATILE SUBSTANCE-ABUSE - A REVIEW OF POSSIBLE LONG-TERM NEUROLOGICAL, INTELLECTUAL AND PSYCHIATRIC SEQUELAE [J].