Solvent inhalation (toluene and n-hexane) during the brain growth spurt impairs the maturation of frontal, parietal and occipital cerebrocortical neurons in rats

被引：7

作者：

Pascual, Rodrigo ^{[1
]}

Aedo, Luz ^{[1
]}

Carlos Meneses, Juan ^{[1
]}

Vergara, Daniela ^{[1
]}

Reyes, Alvaro ^{[1
]}

Bustamante, Carlos ^{[1
]}

机构：

[1] Pontificia Univ Catolica Valparaiso, Fac Ciencias, Escuela Kinesiol, Lab Neurociencias, Valparaiso, Chile

来源：

INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE | 2010年 / 28卷 / 06期

关键词：

Solvent inhalation; Dendritic development; Cortical neurons; Brain growth spurt; DEVELOPMENTAL NEUROTOXICITY; SUBUNIT EXPRESSION; VISUAL-CORTEX; EXPOSURE; BEHAVIOR; ABUSE; SENSITIVITY; RECEPTORS;

D O I：

10.1016/j.ijdevneu.2010.06.003

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Solvent abuse during pregnancy may cause "fetal solvent syndrome", which is characterized by mild brain atrophy and associated with behavioral, cognitive, and emotional abnormalities. The present study investigated whether solvent inhalation during the preweaning period (P2-P21) alters the morphological maturation of frontal, parietal, and occipital cortical neurons. Twelve hours after delivery (postnatal day 0, PO), litters were cross-fostered, culled to 8 pups/dam and housed together with a dam in standard laboratory cages. Litters were randomly assigned to the "air-only" group (n = 64, 8 litters) and to the "solvent-sniffer" group (n = 72, 9 litters). During P2-P21, each animal was exposed daily to either organic solvent vapors (75% toluene and 18% n-hexane, a solvent mixture commonly found in glues and adhesives) or clean air. To determine the impact of early solvent inhalation on cortical neuronal differentiation, brains were stained using the Golgi-Cox-Sholl procedure to quantitatively assess neocortical pyramidal cell dendrogenesis. Preweaning, solvent-exposed animals displayed dramatic impairments in dendritic growth as well as significant reductions in brain weight and size. (C) 2010 ISDN. Published by Elsevier Ltd. All rights reserved.

引用

页码：491 / 495

页数：5

共 38 条

[1] Single-voxel proton MR spectroscopy in toluene abuse [J].

Aydin, K ;

Sencer, S ;

Ogel, K ;

Genchellac, H ;

Demir, T ;

Minareci, O .

MAGNETIC RESONANCE IMAGING, 2003, 21 (07) :777-785

[2] Brain damage results in down-regulation of N-acetylaspartate as a neuronal osmolyte [J].

Baslow, MH ;

Sucko, RF ;

Gaynor, K ;

Bhako, KK ;

Marks, N ;

Saito, M ;

Duff, K ;

Matsuoka, Y ;

Berg, MJ .

NEUROMOLECULAR MEDICINE, 2003, 3 (02) :95-103

[3] Melatonin protects the central nervous system of rats against toluene-containing thinner intoxication by reducing reactive gliosis [J].

Baydas, G ;

Reiter, RJ ;

Nedzvetskii, VS ;

Yasar, A ;

Tuzcu, M ;

Ozveren, F ;

Canatan, H .

TOXICOLOGY LETTERS, 2003, 137 (03) :169-174

[4] Gestational toluene exposure effects on spontaneous and amphetamine-induced locomotor behavior in rats [J].

Bowen, Scott E. ;

Mohammadi, Michael H. ;

Batis, Jeffery C. ;

Hannigan, John H. .

NEUROTOXICOLOGY AND TERATOLOGY, 2007, 29 (02) :236-246

[5] Abuse pattern of gestational toluene exposure and early postnatal development in rats [J].

Bowen, SE ;

Batis, JC ;

Mohammadi, MH ;

Hannigan, JH .

NEUROTOXICOLOGY AND TERATOLOGY, 2005, 27 (01) :105-116

[6] Developmental neurotoxicity of toluene: in vivo and in vitro effects on astroglial cells [J].

Burry, M ;

Guizzetti, M ;

Oberdoerster, J ;

Costa, LG .

DEVELOPMENTAL NEUROSCIENCE, 2003, 25 (01) :14-19

[7] Neonatal toluene exposure alters agonist and antagonist sensitivity and NR2B subunit expression of NMDA receptors in cultured cerebellar granule neurons [J].

Chen, HH ;

Wei, CT ;

Lin, YR ;

Chien, TH ;

Chan, MH .

TOXICOLOGICAL SCIENCES, 2005, 85 (01) :666-674

[8] Toluene exposure during the brain growth spurt reduces behavioral responses to noncompetitive N-methyl-D-aspartate receptor antagonists in adult [J].

Chien, TH ;

Chan, MH ;

Tang, YC ;

Chen, HH .

PSYCHOPHARMACOLOGY, 2005, 182 (04) :468-474

[9] Neurobehavioral disturbances arising from occupational toluene exposure [J].

Chouanière, D ;

Wild, P ;

Fontana, JM ;

Hèry, M ;

Fournier, M ;

Baudin, V ;

Subra, I ;

Rousselle, D ;

Toamain, JP ;

Saurin, S ;

Ardiot, MR .

AMERICAN JOURNAL OF INDUSTRIAL MEDICINE, 2002, 41 (02) :77-88

[10] Translating developmental time across mammalian species [J].

Clancy, B ;

Darlington, RB ;

Finlay, BL .

NEUROSCIENCE, 2001, 105 (01) :7-17

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