LncRNA CCAT2 predicts poor prognosis and regulates growth and metastasis in small cell lung cancer

被引：69

作者：

Chen, Shifeng ^{[1
]}

Wu, Hong ^{[1
]}

Lv, Na ^{[1
]}

Wang, Hongling ^{[1
]}

Wang, Yushu ^{[1
]}

Tang, Qianqing ^{[1
]}

Shao, Huiyuan ^{[1
]}

Sun, Chengming ^{[1
]}

机构：

[1] Yantai Yuhuangding Hosp, Dept Clin Lab, Yantai 264000, Shandong, Peoples R China

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2016年 / 82卷

关键词：

CCAT2; SCLC; LncRNA; Proliferation; Metastasis; LONG NONCODING RNA; ADENOCARCINOMA; PROLIFERATION; PROGRESSION; EXPRESSION; HOTAIR;

D O I：

10.1016/j.biopha.2016.05.017

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

LncRNA colon cancer-associated transcript 2 (CCAT2) was firstly discovered and found overexpressed in colorectal cancer, and identified as is oncogenic lncRNA. However, the significance of CCAT2 in small cell lung cancer (SCLC) remains unclear. The expression of CCAT2 in SCLC tissues and cell lines was detected, and the association between CCAT2 expression and clinicopathological factors was analyzed. Cell proliferation and invasion assays were conducted by using SCLC cell lines transfected with CCAT2-siRNA or NC-siRNA. In our results, CCAT2 expression was elevated in SCLC tissues and cell lines, and correlated with malignant status and poor prognosis of SCLC patients. Furthermore, knockdown of CCAT2 expression effectively suppressed SCLC cell growth and metastasis in vitro. In conclusion, CCAT2 serves as an oncogenic lncRNA, and an independent unfavorable prognostic factor in SCLC patients. (C) 2016 Published by Elsevier Masson SAS.

引用

页码：583 / 588

页数：6

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