Expanded blood volumes contribute to the increased cardiovascular performance of endurance-trained older men

被引:56
作者
Hagberg, JM [1 ]
Goldberg, AP
Lakatta, L
O'Connor, FC
Becker, LC
Lakatta, EG
Fleg, JL
机构
[1] Univ Maryland, Dept Kinesiol, College Pk, MD 20742 USA
[2] Univ Maryland, Ctr Aging, College Pk, MD 20742 USA
[3] Univ Maryland, Sch Med, Geriatr Serv, Dept Med,Div Gerontol, Baltimore, MD 21201 USA
[4] Baltimore Vet Adm Med Ctr, Ctr Geriatr Res Educ & Clin, Baltimore, MD 21201 USA
[5] NIA, Cardiovasc Sci Lab, Ctr Gerontol Res, Baltimore, MD 21224 USA
[6] Johns Hopkins Med Inst, Div Cardiol, Baltimore, MD 21222 USA
关键词
plasma volume; red cell volume; total blood volume; body composition; stroke volume; cardiac output;
D O I
10.1152/jappl.1998.85.2.484
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
To determine whether expanded intravascular volumes contribute to the older athlete's higher exercise stroke volume and maximal oxygen consumption ((V) over dot O-2max), we measured peak upright cycle ergometry cardiac volumes (Tc-99m ventriculography) and plasma (I-125-labeled albumin) and red cell (NaCr51) volumes in 7 endurance-trained and 12 age-matched lean sedentary men. The athletes had similar to 40% higher (V) over dot O-2max values than did the sedentary men and larger relative plasma (46 vs. 38 ml/kg), red cell (30 vs. 26 ml/kg), and total blood volumes (76 vs. 64 ml/kg) (all P < 0.05). Athletes had larger peak cycle ergometer exercise stroke volume indexes (75 vs. 57 ml/m(2), P < 0.05) and 17% larger end-diastolic volume indexes. In the total group, (V) over dot O-2max, correlated with plasma, red cell, and total blood volumes (r = 0.61-0.70, P < 0.01). Peak exercise stroke volume was correlated directly with the blood volume variables (r = 0.59-0.67, P < 0.01). Multiple regression analyses showed that fat-free mass and plasma or total blood volume, but not red cell volume, were independent determinants of (V) over dot O-2max, and peak exercise stroke volume. Plasma and total blood volumes correlated with the stroke volume and end-diastolic volume changes from rest to peak exercise. This suggests that expanded intravascular volumes, particularly plasma and total blood volumes, contribute to the higher peak exercise left ventricular end-diastolic volume, stroke volume, and cardiac output and hence the higher (V) over dot O-2max in master athletes by eliciting both chronic volume overload and increased utilization of the Frank-Starling effect during exercise.
引用
收藏
页码:484 / 489
页数:6
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