Combretastatin a-4 analogs as anticancer agents

被引：151

作者：

Chaudhary, Anurag ^{[1
]}

Pandeya, S. N.

Kumar, P.

Sharma, Py.

Gupta, S.

Soni, N.

Verma, K. K.

Bhardwaj, G.

机构：

[1] Modi Inst Pharmaceut Educ Res, Modinagar 201201, India

[2] Fac Pharm, New Delhi 110062, India

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2007年 / 7卷 / 12期

关键词：

combretastatin A-4; antitubulin; antivascular; cytotoxicity; structure-activity relationship;

D O I：

10.2174/138955707782795647

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Combretastatin A-4 (CA-4) is one of the most potent antimitotic and antiangiogenic agents of natural origin. It has displayed potent antitumor effect in a wide variety of preclinical tumor models. Till date various CA-4 analogs have been synthesized and evaluated for anticancer activity. This review is an attempt to compile the medicinal chemistry of various synthesized CA-4 analogs.

引用

页码：1186 / 1205

页数：20

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