Recent Advances in the Total Synthesis of Clavaminols

被引：1
作者：
Jin, Tian [1 ]
Zhao, Lu [2 ]
Liu, Xiao [1 ]
Sun, Liang [3 ]
Lin, Jia-Fu [1 ]
Zheng, Zhe-Bin [1 ]
机构：
[1] Chengdu Univ, Sichuan Ind Inst Antibiot, Sichuan Educ Dept, Key Lab Med & Edible Plants Resources Dev, Chengdu 610052, Sichuan, Peoples R China
[2] Sichuan Inst Food & Drug Control, Chengdu 611731, Sichuan, Peoples R China
[3] Jilin Prov Peoples Hosp, Dept Pharm, Changchun 130021, Jilin, Peoples R China
来源：
SYNTHESIS-STUTTGART | 2018年 / 50卷 / 23期
关键词：
total synthesis; clavaminols; natural products; long-chain; 2-amino-3-alkanols; antitumor activity; STEREOSELECTIVE TOTAL-SYNTHESIS; METATHESIS REACTIONS; SECONDARY ALCOHOLS; PRACTICAL ROUTE; OXIDATION; (-)-CLAVAMINOL; SPHINGANINE; DERIVATIVES; AMINATION; CHLORIDE;
D O I：
10.1055/s-0037-1610305
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Clavaminols are a new class of long-chain 2-amino-3-lkanols that mostly contain 2R, 3S-configurations. Owing to their interesting molecular architectures and promising activities, they have become popular targets for synthetic organic chemists. In this review, we highlight 12 total syntheses of clavaminols from different research groups during the period 2009 to 2018.
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页码：4569 / 4576
页数：8
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