Adverse effects of isotretinoin: A large, retrospective review

被引:100
作者
Brzezinski, Piotr [1 ,2 ]
Borowska, Katarzyna [3 ]
Chiriac, Anca [4 ,5 ]
Smigielski, Janusz [6 ]
机构
[1] Pomeranian Acad, Inst Biol & Environm Protect, Ul Arciszewskiego 22A, PL-76200 Slupsk, Poland
[2] 6th Mil Support Unit, Dept Dermatol, Os Ledowo 1N, PL-76270 Ustka, Poland
[3] Med Univ Lublin, Dept Histol & Embryol, Expt Cytol Unit, Lublin, Poland
[4] Apollonia Univ Iasi, Dept Dermatophysiol, Str Muzicii 2, Iasi 700399, Romania
[5] Apollonia Univ, Inst Macromol Chem, Nicolina Med Ctr Petru Poni, Iasi, Romania
[6] Med Univ Lodz, Dept Geriatr, HARC, Pl Hallera 1, PL-90647 Lodz, Poland
关键词
acne; 13-cis-retinoic acid; efficacy; isotretinoin; side effects; ORAL ISOTRETINOIN; ACNE-VULGARIS;
D O I
10.1111/dth.12483
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Acne is a very common and disfiguring disease that affects mostly adolescents and, to some extent, adults. The objective of our study was to estimate the adverse effects after isotretinoin by treatment of 3,525 patients due to acne vulgaris in a 5-year observation. Retrospective, comparative study was carried out in Poland and Romania from January 2012 to August 2016. Inclusion criteria into this study were moderate, severe, and nodulocystic inflammatory acne vulgaris. Exclusion criteria were mild acne, pregnant, and lactating women. Statistical analysis was carried out using T test and Chi square. All patients were treated with oral isotretinoin. Patient age ranged from 13-35 years. Dry lips was the most commonly reported adverse effect, affecting 100% of users, followed by xerosis (94.97%) and facial erythema (66.21%). Of all adverse effects, psychiatric symptoms accounted for 25.16%; eye lesions accounted for 8.96%. In lab investigations an increase in the level of total cholesterol and serum triglycerides was observed. This study documents the adverse effect profile of isotretinoin in a large number of patients collected over a period of 4 years. Side effects were mild and well tolerated and did not necessitate stopping the treatment. However, it is important to educate patients about this potential consequence.
引用
收藏
页数:6
相关论文
共 24 条
  • [1] Analysis of clinical efficacy, side effects, and laboratory changes among patients with acne vulgaris receiving single versus twice daily dose of oral isotretinoin
    Ahmad, Hesham M.
    [J]. DERMATOLOGIC THERAPY, 2015, 28 (03) : 151 - 157
  • [2] Ali Jah M. M., 2011, PAK J MED SCI, V27, P196
  • [3] Isotretinoin and Pregnancy Prevention Do We Need to Take a Long, Hard Look at Ourselves?
    Altman, Emily M.
    [J]. JAMA DERMATOLOGY, 2014, 150 (04) : 361 - 362
  • [4] Isotretinoin Exposure during Pregnancy Assessment of Spontaneous Reports in France
    Autret-Leca, Elisabeth
    Kreft-Jais, Carmen
    Elefant, Elisabeth
    Cissoko, Haware
    Darrouzain, Francois
    Grimaldi-Bensouda, Lamiae
    Attia, Sarah
    Jonville-Bera, Annie Pierre
    [J]. DRUG SAFETY, 2010, 33 (08) : 659 - 665
  • [5] Low-dose oral isotretinoin versus topical retinoic acid for photoaging: a randomized, comparative study
    Bagatin, Edileia
    Guadanhim, Lilia R. S.
    Enokihara, Milvia M. S. S.
    Sanudo, Adriana
    Talarico, Sergio
    Miot, Helio A.
    Gibson, Lawrence
    [J]. INTERNATIONAL JOURNAL OF DERMATOLOGY, 2014, 53 (01) : 114 - 122
  • [6] Pro-inflammatory cytokines in patients with various kinds of acne treated with isotretinoin
    Bergler-Czop, Beata
    Brzezinska-Wcislo, Ligia
    [J]. POSTEPY DERMATOLOGII I ALERGOLOGII, 2014, 31 (01): : 21 - 28
  • [7] High-Dose Isotretinoin Treatment and the Rate of Retrial, Relapse, and Adverse Effects in Patients With Acne Vulgaris
    Blasiak, Rachel C.
    Stamey, Christopher R.
    Burkhart, Craig N.
    Lugo-Somolinos, Aida
    Morrell, Dean S.
    [J]. JAMA DERMATOLOGY, 2013, 149 (12) : 1392 - 1398
  • [8] Isotretinoin therapy changes the expression of antimicrobial peptides in acne vulgaris
    Borovaya, Alena
    Dombrowski, Yvonne
    Zwicker, Stephanie
    Olisova, Olga
    Ruzicka, Thomas
    Wolf, Ronald
    Schauber, Juergen
    Sardy, Miklos
    [J]. ARCHIVES OF DERMATOLOGICAL RESEARCH, 2014, 306 (08) : 689 - 700
  • [9] Interpretation of Biochemical Tests Using the Reference Change Value in Monitoring Adverse Effects of Oral Isotretinoin in 102 Ethnic Turkish Patients
    Bugdayci, Guler
    Polat, Mualla
    Oguzman, Hamdi
    Cinpolat, Havva Yasemin
    [J]. LABORATORY MEDICINE, 2016, 47 (03) : 213 - 219
  • [10] Chang L. M., 2014, DERMATOLOGY ONLINE J, V20, P21540