Invasive pulmonary aspergillosis due to Aspergillus terreus value of DNA, galactomannan and (1→3)-β-D-glucan detection in serum samples as an adjunct to diagnosis

被引：19

作者：

Mokaddas, E. ^{[1
]}

Burhamah, M. H. A.

Ahmad, S. ^{[1
]}

Khan, Z. U. ^{[1
]}

机构：

[1] Kuwait Univ, Fac Med, Dept Microbiol, Safat 13060, Kuwait

来源：

JOURNAL OF MEDICAL MICROBIOLOGY | 2010年 / 59卷 / 12期

关键词：

FUNGAL-INFECTIONS; AMPHOTERICIN-B; BRONCHOALVEOLAR LAVAGE; ASSAY; FUMIGATUS; (1-3)-BETA-D-GLUCAN; 1,3-BETA-D-GLUCAN; SUSCEPTIBILITY; EPIDEMIOLOGY; ANTIGENEMIA;

D O I：

10.1099/jmm.0.023630-0

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A case of invasive pulmonary aspergillosis caused by Aspergillus terreus is described The diagnosis was based on demonstration of branched septate hyphae in a sputum specimen and isolation of the fungus in culture The diagnosis was further supported by detection of A terreus-specific DNA, galactomannan (GM) and (1 -> 3)-beta-D-glucan (BDG) in consecutive serum specimens The patient was treated for about 10 weeks with voriconazole The decreasing levels of GM and BDG in serum samples were accompanied by symptomatic and radiological improvement The report highlights the value of surrogate markers in the diagnosis and for monitoring the course of invasive aspergillosis during therapy

引用

页码：1519 / 1523

页数：5

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