Renin-angiotensin-aldosterone system and heart failure: Pathophysiologic and therapeutic aspects

被引：0

作者：

Castaigne, A ^{[1
]}

Benaceraff, S ^{[1
]}

机构：

[1] Hop Henri Mondor, Federat Serv Cardiol, F-94010 Creteil, France

来源：

THERAPIE | 1998年 / 53卷 / 03期

关键词：

renin-angiotensin-aldosterone system; angiotensin converting enzyme inhibitors; heart failure; angiotensin inhibitors;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Renin, angiotensin II and aldosterone levels are elevated in congestive heart failure, especially when diuretics are introduced. This activation is clearly deleterious by elevating myocardial workload and is related to prognosis of heart failure. The link between hormonal activation and prognosis is causal, as hormonal inhibition by converting enzyme inhibitors improves heart failure prognosis. Angiotensin II and aldosterone appears to be toxic for the myocardium. The results of the trial conducted with angiotensin II antagonist losartan confirm data derived from converting-enzyme-inhibitors trials. The exact role of aldosterone is currently being evaluated in the RALES programme.

引用

页码：285 / 289

页数：5

共 13 条

[1] BALL SG, 1993, LANCET, V342, P821
[2] RENIN RELATIONSHIPS IN CONGESTIVE CARDIAC FAILURE, TREATED AND UNTREATED
BROWN, JJ
DAVIES, DL
JOHNSON, VW
LEVER, AF
ROBERTSON, JI
[J]. AMERICAN HEART JOURNAL, 1970, 80 (03) : 329 - +
[3] A COMPARISON OF ENALAPRIL WITH HYDRALAZINE ISOSORBIDE DINITRATE IN THE TREATMENT OF CHRONIC CONGESTIVE-HEART-FAILURE
COHN, JN
JOHNSON, G
ZIESCHE, S
COBB, F
FRANCIS, G
TRISTANI, F
SMITH, R
DUNKMAN, WB
LOEB, H
WONG, ML
BHAT, G
GOLDMAN, S
FLETCHER, RD
DOHERTY, J
HUGHES, CV
CARSON, P
CINTRON, G
SHABETAI, R
HAAKENSON, C
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1991, 325 (05) : 303 - 310
[4] COMPARISON OF NEUROENDOCRINE ACTIVATION IN PATIENTS WITH LEFT-VENTRICULAR DYSFUNCTION WITH AND WITHOUT CONGESTIVE-HEART-FAILURE - A SUBSTUDY OF THE STUDIES OF LEFT-VENTRICULAR DYSFUNCTION (SOLVD)
FRANCIS, GS
BENEDICT, C
JOHNSTONE, DE
KIRLIN, PC
NICKLAS, J
LIANG, CS
KUBO, SH
RUDINTORETSKY, E
YUSUF, S
[J]. CIRCULATION, 1990, 82 (05) : 1724 - 1729
[5] A CLINICAL-TRIAL OF THE ANGIOTENSIN-CONVERTING-ENZYME INHIBITOR TRANDOLAPRIL IN PATIENTS WITH LEFT-VENTRICULAR DYSFUNCTION AFTER MYOCARDIAL-INFARCTION
KOBER, L
TORPPEDERSEN, C
CARLSEN, JE
BAGGER, H
ELIASEN, P
LYNGBORG, K
VIDEBEK, J
COLE, DS
AUCLERT, L
PAULY, NC
ALIOT, E
PERSSON, S
CAMM, AJ
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1995, 333 (25) : 1670 - 1676
[6] NICKLAS JM, 1992, NEW ENGL J MED, V327, P685
[7] EFFECT OF CAPTOPRIL ON MORTALITY AND MORBIDITY IN PATIENTS WITH LEFT-VENTRICULAR DYSFUNCTION AFTER MYOCARDIAL-INFARCTION - RESULTS OF THE SURVIVAL AND VENTRICULAR ENLARGEMENT TRIAL
PFEFFER, MA
BRAUNWALD, E
MOYE, LA
BASTA, L
BROWN, EJ
CUDDY, TE
DAVIS, BR
GELTMAN, EM
GOLDMAN, S
FLAKER, GC
KLEIN, M
LAMAS, GA
PACKER, M
ROULEAU, J
ROULEAU, JL
RUTHERFORD, J
WERTHEIMER, JH
HAWKINS, CM
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1992, 327 (10) : 669 - 677
[8] Pitt B, 1996, AM J CARDIOL, V78, P902
[9] Randomised trial of losartan versus captopril in patients over 65 with heart failure (Evaluation of Losartan in the Elderly Study, ELITE)
Pitt, B
Segal, R
Martinez, FA
Meurers, G
Cowley, AJ
Thomas, I
Deedwania, PC
Ney, DE
Snavely, DB
Chang, PI
[J]. LANCET, 1997, 349 (9054) : 747 - 752
[10] Activation of Neurohumoral Systems in Postinfarction Left Ventricular Dysfunction
Rouleau, Jean L.
de Champlain, Jacques
Klein, Marc
Bichet, Daniel
Moye, Lemuel
Packer, Milton
Dagenais, Gilles R.
Sussex, Bruce
Arnold, J. Malcolm
Sestier, Francois
Parker, John O.
McEwan, Patricia
Bernstein, Victoria
Cuddy, T. Edward
Lamas, Gervasio
Gottlieb, Stephen S.
McCans, John
Nadeau, Claude
Delage, Francois
Hamm, Peggy
Pfeffer, Marc A.
[J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1993, 22 (02) : 390 - 398

← 1 2 →