Expression of S100A8/A9 in HaCaT keratinocytes alters the rate of cell proliferation and differentiation

被引：40

作者：

Voss, Andreas ^{[1
]}

Bode, Guenther ^{[1
]}

Sopalla, Claudia ^{[1
]}

Benedyk, Malgorzata ^{[1
]}

Varga, Georg ^{[1
,2
]}

Boehm, Markus ^{[2
]}

Nacken, Wolfgang ^{[3
]}

Kerkhoff, Claus ^{[1
]}

机构：

[1] Univ Munster, Inst Immunol, D-4400 Munster, Germany

[2] Univ Munster, Dept Dermatol, D-4400 Munster, Germany

[3] Univ Munster, Inst Mol Virol, ZMBE, D-4400 Munster, Germany

来源：

FEBS LETTERS | 2011年 / 585卷 / 02期

关键词：

S100; protein; Epithelial cell; Stress response; Cell growth; Cell differentiation; NF kappa B activation; NF-KAPPA-B; BINDING-PROTEINS; ARACHIDONIC-ACID; NADPH OXIDASE; SKIN; ACTIVATION; KINASE; CANCER; GENES; MICE;

D O I：

10.1016/j.febslet.2010.12.037

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

S100A8/A9 promotes NADPH oxidase in HaCaT keratinocytes and subsequently increases NF kappa B activation, which plays important roles in the balance between epidermal growth and differentiation. S100A8/A9-positive HaCaT cells present with a significantly reduced rate of cell division and greater expression of two keratinocyte differentiation markers, involucrin and filaggrin, than control cells. S100A8/A9 mutants fail to enhance NF kappa B activation, TNF alpha-induced IL-8 gene expression and NF kappa B p65 phosphorylation, and S100A8/A9-positive cells demonstrate better cell survival in forced suspension culture than mutant cells. S100A8/A9 is induced in epithelial cells in response to stress. Therefore, S100A8/A9-mediated growth arrest could have implications for tissue remodeling and repair. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：440 / 446

页数：7

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