Expression of S100A8/A9 in HaCaT keratinocytes alters the rate of cell proliferation and differentiation

被引：40
作者：
Voss, Andreas [1 ]
Bode, Guenther [1 ]
Sopalla, Claudia [1 ]
Benedyk, Malgorzata [1 ]
Varga, Georg [1 ,2 ]
Boehm, Markus [2 ]
Nacken, Wolfgang [3 ]
Kerkhoff, Claus [1 ]
机构：
[1] Univ Munster, Inst Immunol, D-4400 Munster, Germany
[2] Univ Munster, Dept Dermatol, D-4400 Munster, Germany
[3] Univ Munster, Inst Mol Virol, ZMBE, D-4400 Munster, Germany
来源：
FEBS LETTERS | 2011年 / 585卷 / 02期
关键词：
S100; protein; Epithelial cell; Stress response; Cell growth; Cell differentiation; NF kappa B activation; NF-KAPPA-B; BINDING-PROTEINS; ARACHIDONIC-ACID; NADPH OXIDASE; SKIN; ACTIVATION; KINASE; CANCER; GENES; MICE;
D O I：
10.1016/j.febslet.2010.12.037
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
S100A8/A9 promotes NADPH oxidase in HaCaT keratinocytes and subsequently increases NF kappa B activation, which plays important roles in the balance between epidermal growth and differentiation. S100A8/A9-positive HaCaT cells present with a significantly reduced rate of cell division and greater expression of two keratinocyte differentiation markers, involucrin and filaggrin, than control cells. S100A8/A9 mutants fail to enhance NF kappa B activation, TNF alpha-induced IL-8 gene expression and NF kappa B p65 phosphorylation, and S100A8/A9-positive cells demonstrate better cell survival in forced suspension culture than mutant cells. S100A8/A9 is induced in epithelial cells in response to stress. Therefore, S100A8/A9-mediated growth arrest could have implications for tissue remodeling and repair. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：440 / 446
页数：7
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