Discovering New Transmission-Blocking Antimalarial Compounds: Challenges and opportunities

被引：38

作者：

Birkholtz, Lyn-Marie ^{[1
]}

Coetzer, Theresa L. ^{[2
]}

Mancama, Dalu ^{[1
,3
]}

Leroy, Didier ^{[4
]}

Alano, Pietro ^{[5
]}

机构：

[1] Univ Pretoria, Fac Nat & Agr Sci, Ctr Sustainable Malaria Control, Dept Biochem, Pretoria, South Africa

[2] Univ Witwatersrand, Natl Hlth Lab Serv, Fac Hlth Sci, Wits Res Inst Malaria,Dept Mol Med & Haematol, Johannesburg, South Africa

[3] CSIR, Biosci, Pretoria, South Africa

[4] Med Malaria Venture, Geneva, Switzerland

[5] Ist Super Sanita, Dipartimento Malattie Infett Parassitarie & Immun, Rome, Italy

来源：

TRENDS IN PARASITOLOGY | 2016年 / 32卷 / 09期

基金：

英国医学研究理事会;

关键词：

HIGH-THROUGHPUT ASSAY; PLASMODIUM-FALCIPARUM TRANSMISSION; MEMBRANE-FEEDING ASSAY; SEXUAL DEVELOPMENT; SMALL MOLECULES; CELL BIOLOGY; MALARIA; GAMETOCYTES; IDENTIFICATION; PARASITES;

D O I：

10.1016/j.pt.2016.04.017

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

The ability to target human-mosquito parasite transmission challenges global malaria elimination. However, it is not obvious what a transmission-blocking drug will look like; should it target only parasite transmission stages; be combined with a partner drug killing the pathogenic asexual stages; or kill both the sexual and asexual blood stages, preferably displaying polypharmacology? The development of transmission-blocking antimalarials requires objective analyses of the current strategies. Here, pertinent issues and questions regarding the target candidate profile of a transmission-blocking compound, and its role in malaria elimination strategies, are highlighted and novel perspectives proposed. The essential role of a test cascade that integrates screening and validation strategies to identify next-generation transmission-blocking antimalarials is emphasised.

引用

页码：669 / 681

页数：13

共 51 条

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White, Nicholas J. ;

Ashley, Elizabeth A. ;

Recht, Judith ;

Delves, Michael J. ;

Ruecker, Andrea ;

Smithuis, Frank M. ;

Eziefula, Alice C. ;

Bousema, Teun ;

Drakeley, Chris ;

Chotivanich, Kesinee ;

Imwong, Mallika ;

Pukrittayakamee, Sasithon ;

Prachumsri, Jetsumon ;

Chu, Cindy ;

Andolina, Chiara ;

Bancone, Germana ;

Hien, Tran T. ;

Mayxay, Mayfong ;

Taylor, Walter R. J. ;

von Seidlein, Lorenz ;

Price, Ric N. ;

Barnes, Karen I. ;

Djimde, Abdoulaye ;

ter Kuile, Feiko ;

Gosling, Roly ;

Chen, Ingrid ;

Dhorda, Mehul J. ;

Stepniewska, Kasia ;

Guerin, Philippe ;

Woodrow, Charles J. ;

Dondorp, Arjen M. ;

Day, Nicholas P. J. ;

Nosten, Francois H. .

MALARIA JOURNAL, 2014, 13

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