Discovering New Transmission-Blocking Antimalarial Compounds: Challenges and opportunities

被引：37

作者：

Birkholtz, Lyn-Marie ^{[1
]}

Coetzer, Theresa L. ^{[2
]}

Mancama, Dalu ^{[1
,3
]}

Leroy, Didier ^{[4
]}

Alano, Pietro ^{[5
]}

机构：

[1] Univ Pretoria, Fac Nat & Agr Sci, Ctr Sustainable Malaria Control, Dept Biochem, Pretoria, South Africa

[2] Univ Witwatersrand, Natl Hlth Lab Serv, Fac Hlth Sci, Wits Res Inst Malaria,Dept Mol Med & Haematol, Johannesburg, South Africa

[3] CSIR, Biosci, Pretoria, South Africa

[4] Med Malaria Venture, Geneva, Switzerland

[5] Ist Super Sanita, Dipartimento Malattie Infett Parassitarie & Immun, Rome, Italy

来源：

TRENDS IN PARASITOLOGY | 2016年 / 32卷 / 09期

基金：

英国医学研究理事会;

关键词：

HIGH-THROUGHPUT ASSAY; PLASMODIUM-FALCIPARUM TRANSMISSION; MEMBRANE-FEEDING ASSAY; SEXUAL DEVELOPMENT; SMALL MOLECULES; CELL BIOLOGY; MALARIA; GAMETOCYTES; IDENTIFICATION; PARASITES;

D O I：

10.1016/j.pt.2016.04.017

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

The ability to target human-mosquito parasite transmission challenges global malaria elimination. However, it is not obvious what a transmission-blocking drug will look like; should it target only parasite transmission stages; be combined with a partner drug killing the pathogenic asexual stages; or kill both the sexual and asexual blood stages, preferably displaying polypharmacology? The development of transmission-blocking antimalarials requires objective analyses of the current strategies. Here, pertinent issues and questions regarding the target candidate profile of a transmission-blocking compound, and its role in malaria elimination strategies, are highlighted and novel perspectives proposed. The essential role of a test cascade that integrates screening and validation strategies to identify next-generation transmission-blocking antimalarials is emphasised.

引用

页码：669 / 681

页数：13

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