Effects and Mechanisms of Tacrolimus on Development of Murine Th17 Cells

被引：6

作者：

Zhang, X. -J. ^{[1
]}

Kang, Y. -D. ^{[1
]}

Xiao, L. ^{[1
]}

Li, R. -D. ^{[1
]}

Ding, G. -S. ^{[1
]}

Wang, Z. -X. ^{[1
]}

Fu, Z. -R. ^{[1
]}

机构：

[1] Second Mil Med Univ, Shanghai Changzheng Hosp, Dept Organ Transplantat, Shanghai 200003, Peoples R China

来源：

TRANSPLANTATION PROCEEDINGS | 2010年 / 42卷 / 09期

关键词：

T-CELLS; ALLOGRAFT-REJECTION; DIFFERENTIATION; GENERATION; INJURY; IL-17; RESPONSES; PROMOTES; T(H)17; LONG;

D O I：

10.1016/j.transproceed.2010.08.033

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Tacrolimus (Tac, FK506) is a widely used T-cell-targeted immunosuppression drug known as a calcineurin inhibitor. However, its pharmacologic effects on T-helper type 17 (Th17) cells have not been fully elucidated. Herein, we demonstrate that Tac inhibits Th17 cell differentiation and proliferation, and expression of IL-17 messenger RNA. The proposed mechanism is that Tac inhibits calcineurin and T-cell receptor stimulation-induced cell division. Because Th17 cells participate in allograft rejection, the results of the present study suggest a novel model of immunosuppression effects of Tac. In addition, they provide further implications for the therapeutic immunosuppression effects of Tac on allograft rejection.

引用

页码：3779 / 3783

页数：5

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