Comparative Study of the Intensity of Nitric Oxide Production and Copper Content in Hippocampus of Rats After Modeling of Hemorrhagic Stroke and Brain Injury

被引：4

作者：

Andrianov, V. V. ^{[1
,2
]}

Kulchitsky, V. A. ^{[3
]}

Yafarova, G. G. ^{[1
,2
]}

Zamaro, A. S. ^{[3
]}

Tokalchik, Y. P. ^{[3
]}

Bazan, L., V ^{[1
]}

Bogodvid, T. K. ^{[2
,4
]}

Iyudin, V. S. ^{[1
]}

Pashkevich, S. G. ^{[3
]}

Dosina, M. O. ^{[3
]}

Gainutdinov, K. L. ^{[1
,2
]}

机构：

[1] Russian Acad Sci, Zavoisky Phys Tech Inst, Lab Spin Phys & Spin Chem, Sibirsky Tract 10-7, Kazan 420029, Tatarstan, Russia

[2] Kazan Fed Univ, Kazan, Russia

[3] Natl Acad Sci, Brain Ctr, Inst Physiol, Minsk, BELARUS

[4] Volga Reg State Univ Phys Culture Sport & Tourism, Kazan, Russia

来源：

APPLIED MAGNETIC RESONANCE | 2021年 / 52卷 / 11期

关键词：

DINITROSYL IRON COMPLEXES; TISSUES; NO; DITHIOCARBAMATE; EPR; DYSFUNCTION; ADAPTATION; STORAGE;

D O I：

10.1007/s00723-021-01423-1

中图分类号：

O64 [物理化学（理论化学）、化学物理学]; O56 [分子物理学、原子物理学];

学科分类号：

070203 ; 070304 ; 081704 ; 1406 ;

摘要：

A comparative experimental analysis of intensity of nitric oxide (NO) production and the copper content in the tissues of hippocampus of male Wistar rats after modeling of hemorrhagic stroke and brain injury was conducted using EPR spectroscopy. Modeling of hemorrhagic stroke was carried out by microinjection of 500 nl of autologous blood into the brain to a depth of 5.0 mm (hippocampus) on the left side. Brain injury was performed by removing a piece of nerve tissue from 5.0 mm depth on the left side of hippocampus. It was registered a significant decrease in the NO content in hippocampus by 36 +/- 17% on the 3rd day after modeling of hemorrhagic stroke together with decrease by an average of 24 +/- 14% of the copper content. There were no significant changes in the NO level in hippocampus found neither on the 3rd day nor on the 7th day after brain injury modeling. There was also no change in copper content. Thus, it was experimentally demonstrated that modeling of brain injury, in contrast to hypoxia induced by hemorrhagic stroke, was not accompanied with significant changes in NO production in hippocampus of rat.

引用

页码：1657 / 1669

页数：13

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